| Gene Information | |
|---|---|
| Gene Name | EPN3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 632 |
| Protein Names | Epsin-3 (EPS-15-interacting protein 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000049283 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H201 |
| Gene Card | EPN3 |
| Uniprot ID | Q9H201 |
| Pfam | PF01417; PF02809 |
| In ASD | no |
| Allosteric Prediction | no (-1.063855069) |
| Ortholog in Animals | Alpaca_ EPN3 ( ortholog_one2one ) Dog_ EPN3 ( ortholog_one2one ) GuineaPig_ EPN3 ( ortholog_one2one ) Macaque_ EPN3 ( ortholog_one2one ) Mouse_ Epn3 ( ortholog_one2one ) Pig_ EPN3 ( ortholog_one2one ) Rat_ Epn3 ( ortholog_one2one ) Rabbit_ EPN3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ENTHD1, MYCBPAP, CLINT1, EPN2, EPN1 |
| Tissue | NA |
| Tissue Specificity | Detected in migrating keratinocytes from wounded skin, but not in differentiating keratinocytes or in normal skin. Detected in chronic wounds, basal cell carcinoma and ulcerative colitis. {ECO:0000269|PubMed:11359770}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.058824(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs4794159 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11359770}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11359770}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:11359770}. Nucleus {ECO:0000305|PubMed:11359770}. Note=Concentrated in the perinuclear region and associated with clathrin-coated vesicles close to the cell periphery. May shuttle to the nucleus. |
| Mouse PG classification | NA |
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