| Gene Information | |
|---|---|
| Gene Name | EPN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 576 |
| Protein Names | Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1) |
| Target Name | epsin-1 |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000063245 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y6I3 |
| Gene Card | EPN1 |
| Uniprot ID | Q9Y6I3 |
| Pfam | PF01417; PF02809 |
| In ASD | no |
| Allosteric Prediction | yes (0.247091288) |
| Ortholog in Animals | Alpaca_ EPN1 ( ortholog_one2one ) Dog_ EPN1 ( ortholog_one2one ) Macaque_ EPN1 ( ortholog_one2one ) Mouse_ Epn1 ( ortholog_one2one ) Pig_ EPN1 ( ortholog_one2one ) Rat_ Epn1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ENTHD1, MYCBPAP, CLINT1, EPN3, EPN2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002202(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1INZ (NMR - ) 1KYD (X-ray 2.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Membrane, clathrin-coated pit {ECO:0000250}. Note=Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Detected in presynaptic nerve terminals and in Golgi stacks. May shuttle to the nucleus when associated with ZBTB16/ZNF145 (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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