| Gene Information | |
|---|---|
| Gene Name | EPHB6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1021 |
| Protein Names | Ephrin type-B receptor 6 (HEP) (Tyrosine-protein kinase-defective receptor EPH-6) |
| Target Name | ephrin type-b receptor 6 |
| Target Type | NA |
| Gene Age | 424 ( ENSG00000106123 ) 3 ( ENSG00000275482 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | O15197 |
| Gene Card | EPHB6 |
| Uniprot ID | O15197 |
| Pfam | PF14575; PF01404; PF07699; PF00041; PF07714; PF07647 |
| In ASD | no |
| Allosteric Prediction | no (-0.173811203) |
| Ortholog in Animals | Alpaca_ EPHB6 ( ortholog_one2one ) Dog_ EPHB6 ( ortholog_one2one ) GuineaPig_ EPHB6 ( ortholog_one2one ) Macaque_ EPHB6 ( ortholog_one2one ) Mouse_ Ephb6 ( ortholog_one2one ) Pig_ EPHB6 ( ortholog_one2one ) Rat_ Ephb6 ( ortholog_one2one ) Rabbit_ EPHB6 ( ortholog_one2one ) |
| Ohnologs | EPHB4, EPHA8, EPHA4, EPHB2, EPHA2, EPHB1, EPHB3 |
| Paralogs | EPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1, MET |
| Tissue | NA |
| Tissue Specificity | Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at protein level). Strong expression in brain and pancreas, and weak expression in other tissues, such as heart, placenta, lung, liver, skeletal muscle and kidney. Expressed in breast non invasive tumors but not in metastatic lesions. Isoform 3 is expressed in cell lines of glioblastomas, anaplastic astrocytomas, gliosarcomas and astrocytomas. Isoform 3 is not detected in normal tissues. {ECO:0000269|PubMed:18754880, ECO:0000269|PubMed:19234485, ECO:0000269|PubMed:9207182}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 7K7J (X-ray 3.00A ) |
| DBSNP | rs8177173 rs8177143 rs55728646 rs8177146 rs35189999 rs8177175 rs35984674 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted {ECO:0000305}. |
| Mouse PG classification | NA |
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