| Gene Information | |
|---|---|
| Gene Name | EPHB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 984 |
| Protein Names | Ephrin type-B receptor 1 (EC 2.7.10.1) (ELK) (EPH tyrosine kinase 2) (EPH-like kinase 6) (EK6) (hEK6) (Neuronally-expressed EPH-related tyrosine kinase) (NET) (Tyrosine-protein kinase receptor EPH-2) |
| Target Name | ephrin type-b receptor 1 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000154928 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P54762 |
| Gene Card | EPHB1 |
| Uniprot ID | P54762 |
| Pfam | PF14575; PF01404; PF00041; PF07714; PF00536 |
| In ASD | no |
| Allosteric Prediction | yes (0.652140389) |
| Ortholog in Animals | Alpaca_ EPHB1 ( ortholog_one2one ) Dog_ EPHB1 ( ortholog_one2one ) GuineaPig_ EPHB1 ( ortholog_one2one ) Macaque_ EPHB1 ( ortholog_one2one ) Mouse_ Ephb1 ( ortholog_one2one ) Pig_ EPHB1 ( ortholog_one2one ) Rat_ Ephb1 ( ortholog_one2one ) Rabbit_ EPHB1 ( ortholog_one2one ) |
| Ohnologs | EPHB6, EPHA1, EPHB3, EPHB4, EPHA8, EPHA6, EPHA4, EPHB2, EPHA2, EPHA10 |
| Paralogs | EPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1, MET |
| Tissue | NA |
| Tissue Specificity | Preferentially expressed in brain. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2DJS (NMR - ) 2EAO (NMR - ) 3ZFX (X-ray 2.50A ) 5MJA (X-ray 2.14A ) 5MJB (X-ray 2.23A ) 6UMW (X-ray 1.98A ) 7KPL (X-ray 2.71A ) 7KPM (X-ray 1.61A ) |
| DBSNP | rs55650774 rs1042794 rs1042793 rs1042789 rs56396912 rs1042788 rs1338928289 rs1042785 rs56345346 rs1042784 rs56186270 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:18034775}; Single-pass type I membrane protein {ECO:0000269|PubMed:18034775}. Early endosome membrane {ECO:0000269|PubMed:18034775}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8CBF3}. |
| Mouse PG classification | NA |
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