| Gene Information | |
|---|---|
| Gene Name | EPCAM |
| Organism | Homo sapiens (Human) |
| Gene Length | 314 |
| Protein Names | Epithelial cell adhesion molecule (Ep-CAM) (Adenocarcinoma-associated antigen) (Cell surface glycoprotein Trop-1) (Epithelial cell surface antigen) (Epithelial glycoprotein) (EGP) (Epithelial glycoprotein 314) (EGP314) (hEGP314) (KS 1/4 antigen) (KSA) (Major gastrointestinal tumor-associated protein GA733-2) (Tumor-associated calcium signal transducer 1) (CD antigen CD326) |
| Target Name | epithelial cell adhesion molecule |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000119888 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P16422 |
| Gene Card | EPCAM |
| Uniprot ID | P16422 |
| Pfam | PF18635; PF00086 |
| In ASD | no |
| Allosteric Prediction | yes (0.116010275) |
| Ortholog in Animals | Alpaca_ EPCAM ( ortholog_one2one ) Dog_ EPCAM ( ortholog_one2one ) GuineaPig_ EPCAM ( ortholog_one2one ) Macaque_ EPCAM ( ortholog_one2one ) Mouse_ Epcam ( ortholog_one2one ) Pig_ EPCAM ( ortholog_one2one ) Rat_ Epcam ( ortholog_one2one ) Rabbit_ EPCAM ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TACSTD2 |
| Tissue | NA |
| Tissue Specificity | Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma. {ECO:0000269|PubMed:20064925}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4MZV (X-ray 1.86A ) 6I07 (X-ray 2.35A ) |
| DBSNP | rs267606785 rs1126497 |
| Subcellular location [CC] | Lateral cell membrane {ECO:0000269|PubMed:15195135, ECO:0000269|PubMed:16054130, ECO:0000269|PubMed:19785009}; Single-pass type I membrane protein {ECO:0000269|PubMed:16054130}. Cell junction, tight junction {ECO:0000269|PubMed:16054130}. Note=Colocalizes with CLDN7 at the lateral cell membrane and tight junction. {ECO:0000269|PubMed:16054130}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |