Gene Information
Gene NameEPB41L4B
OrganismHomo sapiens (Human)
Gene Length900
Protein NamesBand 4.1-like protein 4B (Erythrocyte membrane protein band 4.1-like 4B) (FERM-containing protein CG1) (Protein EHM2)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000095203 )
Evolutionary StageOpisthokonta
AlphaFoldDBQ9H329
Gene CardEPB41L4B
Uniprot IDQ9H329
PfamPF08736; PF09380; PF00373; PF09379
In ASDno
Allosteric Predictionno (-0.178060502)
Ortholog in AnimalsAlpaca_ EPB41L4B ( ortholog_one2one )
Dog_ EPB41L4B ( ortholog_one2one )
GuineaPig_ EPB41L4B ( ortholog_one2one )
Macaque_ EPB41L4B ( ortholog_one2one )
Mouse_ Epb41l4b ( ortholog_one2one )
Pig_ EPB41L4B ( ortholog_one2one )
Rat_ Epb41l4b ( ortholog_one2one )
Rabbit_ EPB41L4B ( ortholog_one2one )
OhnologsEPB41L5
ParalogsEPB41L2, FRMD3, EPB41, EPB41L5, FRMD6, FRMD5, EPB41L4A, MYLIP, EPB41L3, EPB41L1
Tissuepancreas
Tissue SpecificityExpressed at higher levels in acute wounds than chronic wounds with increased expression in healing wounds, especially at the leading wound edge (PubMed:23664528). Isoform 1 is highly expressed in brain. Isoform 2 is highly expressed in testis with lower levels in prostate and breast (PubMed:14521927). {ECO:0000269|PubMed:14521927, ECO:0000269|PubMed:23664528}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs3750450 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:22006950}. Cell junction, tight junction {ECO:0000269|PubMed:22006950}. Note=Accumulates along apical cell-cell boundaries and is also detected in the cytoplasm in a punctate manner. {ECO:0000269|PubMed:22006950}.
Mouse PG classificationNA
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