| Gene Information | |
|---|---|
| Gene Name | EIF2S3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 472 |
| Protein Names | Eukaryotic translation initiation factor 2 subunit 3 (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF-2-gamma X) (eIF-2gX) |
| Target Name | eukaryotic translation initiation factor 2 subunit 3 |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000130741 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | P41091 |
| Gene Card | EIF2S3 |
| Uniprot ID | P41091 |
| Pfam | PF09173; PF00009; PF03144 |
| In ASD | no |
| Allosteric Prediction | yes (0.12659737) |
| Ortholog in Animals | Macaque_ EIF2S3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | EIF2S3B, EFTUD2, GTPBP1, GUF1, EIF5B, MTIF2, EEF2, EFL1, GSPT2, EEFSEC, EEF1A1, EEF1A2, HBS1L, GTPBP2, GFM2, GFM1, GSPT1, TUFM |
| Tissue | NA |
| Tissue Specificity | Expressed in testis, brain, liver and muscle. {ECO:0000269|PubMed:9736774}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6FEC (EM 6.30A ) 6K71 (EM 4.30A ) 6K72 (EM 4.60A ) 6O81 (EM 3.21A ) 6O85 (EM 3.03A ) 6YBV (EM 3.80A ) 6ZMW (EM 3.70A ) 6ZP4 (EM 2.90A ) 7A09 (EM 3.50A ) 7D43 (EM 4.30A ) 7F66 (EM 2.76A ) 7F67 (EM 3.59A ) 7QP6 (EM 4.70A ) 7QP7 (EM 3.70A ) |
| DBSNP | rs1057515578 rs16997659 rs886040855 rs886040856 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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