| Gene Information | |
|---|---|
| Gene Name | ENPP6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 440 |
| Protein Names | Glycerophosphocholine cholinephosphodiesterase ENPP6 (GPC-Cpde) (EC 3.1.4.-) (EC 3.1.4.38) (Choline-specific glycerophosphodiester phosphodiesterase) (Ectonucleotide pyrophosphatase/phosphodiesterase family member 6) (E-NPP 6) (NPP-6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000164303 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q6UWR7 |
| Gene Card | ENPP6 |
| Uniprot ID | Q6UWR7 |
| Pfam | PF01663 |
| In ASD | no |
| Allosteric Prediction | no (-0.585266951) |
| Ortholog in Animals | Alpaca_ ENPP6 ( ortholog_one2one ) Dog_ ENPP6 ( ortholog_one2one ) GuineaPig_ ENPP6 ( ortholog_one2one ) Macaque_ ENPP6 ( ortholog_one2one ) Mouse_ Enpp6 ( ortholog_one2one ) Pig_ ENPP6 ( ortholog_one2one ) Rat_ Enpp6 ( ortholog_one2one ) Rabbit_ ENPP6 ( ortholog_one2one ) |
| Ohnologs | ENPP4, ENPP5 |
| Paralogs | ENPP2, ENPP4, ENPP5, ENPP7, ENPP1, ENPP3 |
| Tissue | kidney, ovary |
| Tissue Specificity | Predominantly expressed in kidney and brain. In the kidney, expressed specifically in the proximal tubules and thin descending limbs of Henle (at protein level). {ECO:0000269|PubMed:15788404}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs4488969 rs4479748 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:15788404}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:15788404}. Note=A small amount of the protein may be found in the extracellular milieu. |
| Mouse PG classification | NA |
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