| Gene Information | |
|---|---|
| Gene Name | ENPP4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 453 |
| Protein Names | Bis(5'-adenosyl)-triphosphatase ENPP4 (EC 3.6.1.29) (AP3A hydrolase) (AP3Aase) (Ectonucleotide pyrophosphatase/phosphodiesterase family member 4) (E-NPP 4) (NPP-4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000001561 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y6X5 |
| Gene Card | ENPP4 |
| Uniprot ID | Q9Y6X5 |
| Pfam | PF01663 |
| In ASD | no |
| Allosteric Prediction | no (-0.346155597) |
| Ortholog in Animals | Alpaca_ ENPP4 ( ortholog_one2one ) Dog_ ENPP4 ( ortholog_one2one ) GuineaPig_ ENPP4 ( ortholog_one2one ) Macaque_ ENPP4 ( ortholog_one2one ) Mouse_ Enpp4 ( ortholog_one2one ) Pig_ ENPP4 ( ortholog_one2one ) Rat_ Enpp4 ( ortholog_one2one ) Rabbit_ ENPP4 ( ortholog_one2one ) |
| Ohnologs | ENPP6 |
| Paralogs | ENPP2, ENPP5, ENPP6, ENPP7, ENPP1, ENPP3 |
| Tissue | NA |
| Tissue Specificity | Expressed on the surface of vascular endothelia. {ECO:0000269|PubMed:22995898}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4LQY (X-ray 1.54A ) 4LR2 (X-ray 1.50A ) |
| DBSNP | rs7451713 rs9381429 rs16874289 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:22995898}; Single-pass type I membrane protein {ECO:0000269|PubMed:22995898}. |
| Mouse PG classification | NA |
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