| Gene Information | |
|---|---|
| Gene Name | ENOX2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 610 |
| Protein Names | Ecto-NOX disulfide-thiol exchanger 2 (APK1 antigen) (Cytosolic ovarian carcinoma antigen 1) (Tumor-associated hydroquinone oxidase) (tNOX) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)] |
| Target Name | ecto-nox disulfide-thiol exchanger 2 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000165675 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q16206 |
| Gene Card | ENOX2 |
| Uniprot ID | Q16206 |
| Pfam | PF00076 |
| In ASD | no |
| Allosteric Prediction | no (-0.137913222) |
| Ortholog in Animals | Alpaca_ ENOX2 ( ortholog_one2one ) Dog_ ENOX2 ( ortholog_one2one ) GuineaPig_ ENOX2 ( ortholog_one2one ) Macaque_ ENOX2 ( ortholog_one2one ) Mouse_ Enox2 ( ortholog_one2one ) Pig_ ENOX2 ( ortholog_one2one ) Rat_ Enox2 ( ortholog_one2one ) Rabbit_ ENOX2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ENOX1 |
| Tissue | NA |
| Tissue Specificity | Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Not found in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed into serum by cancer cells. Found on the cell borders of renal, kidney and ovarian carcinomas but not on the borders of surrounding non-cancerous stromal cells. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs754363472 |
| Subcellular location [CC] | Cell membrane. Secreted, extracellular space. Note=Extracellular and plasma membrane-associated. |
| Mouse PG classification | NA |
| click here to return to the previous page | |