| Gene Information | |
|---|---|
| Gene Name | ENOX1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 643 |
| Protein Names | Ecto-NOX disulfide-thiol exchanger 1 (Candidate growth-related and time keeping constitutive hydroquinone [NADH] oxidase) (cCNOX) (Cell proliferation-inducing gene 38 protein) (Constitutive Ecto-NOX) (cNOX) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000120658 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8TC92 |
| Gene Card | ENOX1 |
| Uniprot ID | Q8TC92 |
| Pfam | PF00076 |
| In ASD | no |
| Allosteric Prediction | no (-1.291833353) |
| Ortholog in Animals | Alpaca_ ENOX1 ( ortholog_one2one ) Dog_ ENOX1 ( ortholog_one2one ) GuineaPig_ ENOX1 ( ortholog_one2one ) Macaque_ ENOX1 ( ortholog_one2one ) Mouse_ Enox1 ( ortholog_one2one ) Pig_ ENOX1 ( ortholog_one2one ) Rat_ Enox1 ( ortholog_one2one ) Rabbit_ ENOX1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ENOX2 |
| Tissue | NA |
| Tissue Specificity | Expressed in lymphocyte cells, breast and breast cancer (at protein level). Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Found also in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed into serum by cancer cells. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs7338624 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:11360993}. Secreted, extracellular space {ECO:0000269|PubMed:11360993}. Note=Extracellular and plasma membrane-associated. |
| Mouse PG classification | NA |
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