| Gene Information | |
|---|---|
| Gene Name | ENO2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 434 |
| Protein Names | Gamma-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 2) (Neural enolase) (Neuron-specific enolase) (NSE) |
| Target Name | gamma-enolase |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000111674 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P09104 |
| Gene Card | ENO2 |
| Uniprot ID | P09104 |
| Pfam | PF00113; PF03952 |
| In ASD | no |
| Allosteric Prediction | yes (0.858016114) |
| Ortholog in Animals | Alpaca_ ENO2 ( ortholog_one2one ) Dog_ ENO2 ( ortholog_one2one ) GuineaPig_ ENO2 ( ortholog_one2one ) Macaque_ ENO2 ( ortholog_one2one ) Mouse_ Eno2 ( ortholog_one2one ) Pig_ ENO2 ( ortholog_one2one ) Rat_ Eno2 ( ortholog_one2one ) Rabbit_ ENO2 ( ortholog_one2one ) |
| Ohnologs | ENO3, ENO1 |
| Paralogs | ENO3, ENO1, ENO4 |
| Tissue | NA |
| Tissue Specificity | The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.006061(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1TE6 (X-ray 1.80A ) 2AKM (X-ray 1.92A ) 2AKZ (X-ray 1.36A ) 3UCC (X-ray 1.50A ) 3UCD (X-ray 1.41A ) 3UJE (X-ray 1.55A ) 3UJF (X-ray 2.10A ) 3UJR (X-ray 1.40A ) 3UJS (X-ray 1.65A ) 4ZA0 (X-ray 2.31A ) 4ZCW (X-ray 1.99A ) 5EU9 (X-ray 2.05A ) 5IDZ (X-ray 2.63A ) 5TD9 (X-ray 2.32A ) 5TIJ (X-ray 2.63A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form. {ECO:0000250}. |
| Mouse PG classification | NA |
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