| Gene Information | |
|---|---|
| Gene Name | ENO1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 434 |
| Protein Names | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) |
| Target Name | alpha-enolase |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000074800 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P06733 |
| Gene Card | ENO1 |
| Uniprot ID | P06733 |
| Pfam | PF00113; PF03952 |
| In ASD | no |
| Allosteric Prediction | yes (1.18461563) |
| Ortholog in Animals | Alpaca_ ENO1 ( ortholog_one2one ) GuineaPig_ ENO1 ( ortholog_one2one ) Mouse_ Eno1 ( ortholog_one2many ) Mouse_ Eno1b ( ortholog_one2many ) Pig_ ENO1 ( ortholog_one2one ) |
| Ohnologs | ENO3, ENO2 |
| Paralogs | ENO3, ENO2, ENO4 |
| Tissue | NA |
| Tissue Specificity | The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2PSN (X-ray 2.20A ) 3B97 (X-ray 2.20A ) 5JLZ (X-ray 1.99A ) 5LAX (X-ray 2.60A ) 5NI9 (X-ray 1.33A ) 5NIG (X-ray 1.35A ) 5OCK (X-ray 1.60A ) |
| DBSNP | rs11544513 rs11544514 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:10802057}. Cell membrane {ECO:0000269|PubMed:10802057}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000269|PubMed:10802057}. Note=Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form. ENO1 is localized to the M line.; [Isoform MBP-1]: Nucleus. |
| Mouse PG classification | NA |
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