| Gene Information | |
|---|---|
| Gene Name | ENDOV |
| Organism | Homo sapiens (Human) |
| Gene Length | 282 |
| Protein Names | Endonuclease V (hEndoV) (EC 3.1.26.-) (Inosine-specific endoribonuclease) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000173818 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q8N8Q3 |
| Gene Card | ENDOV |
| Uniprot ID | Q8N8Q3 |
| Pfam | PF04493 |
| In ASD | no |
| Allosteric Prediction | no (-1.277628158) |
| Ortholog in Animals | Alpaca_ ENDOV ( ortholog_one2one ) Dog_ ENDOV ( ortholog_one2one ) GuineaPig_ ENDOV ( ortholog_one2one ) Mouse_ Endov ( ortholog_one2one ) Pig_ ENDOV ( ortholog_one2one ) Rat_ Endov ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4NSP (X-ray 2.30A ) 6OZE (X-ray 1.50A ) |
| DBSNP | rs35549084 rs34933300 rs41298706 rs41299812 rs35929621 |
| Subcellular location [CC] | [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:23912718, ECO:0000269|PubMed:31703097}. Nucleus, nucleolus {ECO:0000269|PubMed:23139746, ECO:0000269|PubMed:31703097}. Cytoplasm, Stress granule {ECO:0000269|PubMed:27573237}. Note=Relocalizes to cytoplasmic stress granules upon cellular stress where it colocalizes with PABPC1. {ECO:0000269|PubMed:27573237}.; [Isoform 6]: Cytoplasm {ECO:0000269|PubMed:31703097}. Nucleus, nucleolus {ECO:0000269|PubMed:31703097}. Cytoplasm, Stress granule {ECO:0000269|PubMed:31703097}. Note=Relocalizes to cytoplasmic stress granules upon cellular stress. {ECO:0000269|PubMed:31703097}.; [Isoform 7]: Cytoplasm {ECO:0000269|PubMed:31703097}. Nucleus, nucleolus {ECO:0000269|PubMed:31703097}. Cytoplasm, Stress granule {ECO:0000269|PubMed:31703097}. Note=Relocalizes to cytoplasmic stress granules upon cellular stress. {ECO:0000269|PubMed:31703097}. |
| Mouse PG classification | NA |
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