| Gene Information | |
|---|---|
| Gene Name | EMRE |
| Organism | Homo sapiens (Human) |
| Gene Length | 107 |
| Protein Names | Essential MCU regulator, mitochondrial (Single-pass membrane protein with aspartate-rich tail 1, mitochondrial) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9H4I9 |
| Gene Card | SMDT1 |
| Uniprot ID | Q9H4I9 |
| Pfam | PF10161 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.22(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6K7X (EM 3.27A ) 6K7Y (EM 3.60A ) 6O58 (EM 3.80A ) 6O5B (EM 3.60A ) 6WDN (EM 3.20A ) 6WDO (EM 3.60A ) 6XJV (EM 4.17A ) 6XJX (EM 4.60A ) |
| DBSNP | rs17852210 |
| Subcellular location [CC] | Mitochondrion inner membrane {ECO:0000269|PubMed:24231807, ECO:0000269|PubMed:26774479, ECO:0000269|PubMed:27099988, ECO:0000269|PubMed:27642048}; Single-pass membrane protein {ECO:0000269|PubMed:24231807, ECO:0000269|PubMed:27099988}. Note=MAIP1 is required to assist sorting of EMRE/SMDT1 into mitochondrion by protecting EMRE/SMDT1 against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB) (PubMed:27642048). {ECO:0000269|PubMed:27642048}. |
| Mouse PG classification | NA |
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