| Gene Information | |
|---|---|
| Gene Name | EMR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 823 |
| Protein Names | Adhesion G protein-coupled receptor E2 (EGF-like module receptor 2) (EGF-like module-containing mucin-like hormone receptor-like 2) (CD antigen CD312) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9UHX3 |
| Gene Card | ADGRE2 |
| Uniprot ID | Q9UHX3 |
| Pfam | PF00002; PF07645; PF01825 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expression is restricted to myeloid cells. Highest expression was found in peripheral blood leukocytes, followed by spleen and lymph nodes, with intermediate to low levels in thymus, bone marrow, fetal liver, placenta, and lung, and no expression in heart, brain, skeletal muscle, kidney, or pancreas. Expression is also detected in monocyte/macrophage and Jurkat cell lines but not in other cell lines tested. High expression in mast cells (PubMed:26841242). {ECO:0000269|PubMed:10903844, ECO:0000269|PubMed:11994511, ECO:0000269|PubMed:26841242}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2BO2 (X-ray 2.60A ) 2BOU (X-ray 1.90A ) 2BOX (X-ray 2.50A ) |
| DBSNP | rs35612307 rs199718602 rs4410209 rs2524383 rs3752187 rs57865820 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:22310662, ECO:0000269|PubMed:26841242}; Multi-pass membrane protein. Cell projection, ruffle membrane {ECO:0000269|PubMed:17928360}; Multi-pass membrane protein. Note=Localized at the leading edge of migrating cells. {ECO:0000269|PubMed:17928360}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |