| Gene Information | |
|---|---|
| Gene Name | EMP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 167 |
| Protein Names | Epithelial membrane protein 2 (EMP-2) (Protein XMP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000213853 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P54851 |
| Gene Card | EMP2 |
| Uniprot ID | P54851 |
| Pfam | PF00822 |
| In ASD | no |
| Allosteric Prediction | no (-0.205812334) |
| Ortholog in Animals | Alpaca_ EMP2 ( ortholog_one2one ) GuineaPig_ EMP2 ( ortholog_one2one ) Macaque_ EMP2 ( ortholog_one2one ) Mouse_ Emp2 ( ortholog_one2one ) Pig_ EMP2 ( ortholog_one2one ) Rat_ Emp2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | EMP1, PMP22, EMP3, GSG1, GSG1L, LIM2, TMEM202, NKG7, GSG1L2, CLDND2 |
| Tissue | NA |
| Tissue Specificity | Expressed in ciliary body epithelia, sclera, cornea, and retinal pigment epithelium (at protein level) (PubMed:12710941). Expressed in lung and endometrial tissue; expression is particularly abundant in secretory endometrium (at protein level) (PubMed:12710941). Expressed in placental villous syncytiotrophoblasts and cytotrophoblasts and on the membrane of interstitial trophoblasts (at protein level) (PubMed:28295343). {ECO:0000269|PubMed:12710941, ECO:0000269|PubMed:28295343}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs730882194 rs587777482 |
| Subcellular location [CC] | Golgi apparatus membrane {ECO:0000269|PubMed:18400107}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:12107182, ECO:0000269|PubMed:18400107, ECO:0000269|PubMed:21637765, ECO:0000269|PubMed:28295343}. Apical cell membrane {ECO:0000250|UniProtKB:O88662}. Membrane raft {ECO:0000269|PubMed:21637765}. Cytoplasm {ECO:0000269|PubMed:21637765}. Nucleus {ECO:0000250|UniProtKB:Q66HH2}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O88662}. Note=Localizes in cytoplasm, foot processes and cell bodies of podocytes and nucleus of endothelial cells of kidney. Localizes to the apical cell surface in the luminal epithelium and glandular epithelium. Colocalized with ITGB1 and GPI-anchor proteins on plasma membrane. {ECO:0000250|UniProtKB:O88662, ECO:0000250|UniProtKB:Q66HH2}. |
| Mouse PG classification | NA |
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