| Gene Information | |
|---|---|
| Gene Name | EML4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 981 |
| Protein Names | Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000143924 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9HC35 |
| Gene Card | EML4 |
| Uniprot ID | Q9HC35 |
| Pfam | PF03451; PF00400 |
| In ASD | no |
| Allosteric Prediction | yes (0.147345258) |
| Ortholog in Animals | Alpaca_ EML4 ( ortholog_one2one ) Dog_ EML4 ( ortholog_one2one ) GuineaPig_ EML4 ( ortholog_one2one ) Macaque_ EML4 ( ortholog_one2one ) Mouse_ Eml4 ( ortholog_one2one ) Pig_ EML4 ( ortholog_one2one ) Rat_ Eml4 ( ortholog_one2one ) Rabbit_ EML4 ( ortholog_one2one ) |
| Ohnologs | EML1, EML2, EML3, EML5 |
| Paralogs | WDR90, CFAP52, CFAP44, EML5, EML3, CFAP251, EML6, EML1, EML2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 4CGC (X-ray 2.90A ) |
| DBSNP | rs6736913 rs10202624 rs28651764 rs28364731 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:31409757, ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:16890222}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526}. Midbody {ECO:0000269|PubMed:25789526}. Note=Localizes to microtubules (MTs) during interphase with a significantly reduced affinity for MTs during mitosis. {ECO:0000269|PubMed:31409757}. |
| Mouse PG classification | NA |
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