| Gene Information | |
|---|---|
| Gene Name | DOCK5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1870 |
| Protein Names | Dedicator of cytokinesis protein 5 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000147459 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H7D0 |
| Gene Card | DOCK5 |
| Uniprot ID | Q9H7D0 |
| Pfam | PF06920; PF20422; PF20421; PF14429; PF16172; PF00018 |
| In ASD | yes |
| Allosteric Prediction | yes (0.502067256) |
| Ortholog in Animals | Alpaca_ DOCK5 ( ortholog_one2one ) Dog_ DOCK5 ( ortholog_one2one ) GuineaPig_ DOCK5 ( ortholog_one2one ) Macaque_ DOCK5 ( ortholog_one2one ) Mouse_ Dock5 ( ortholog_one2one ) Pig_ DOCK5 ( ortholog_one2one ) Rat_ Dock5 ( ortholog_one2one ) Rabbit_ DOCK5 ( ortholog_one2one ) |
| Ohnologs | DOCK1, DOCK2 |
| Paralogs | DOCK6, DOCK9, DOCK8, DOCK2, DOCK1, DOCK4, DOCK10, DOCK3, DOCK11, DOCK7 |
| Tissue | globus.pallidus, substantia.nigra |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);0.058983(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7DPA (EM 3.80A ) |
| DBSNP | rs17053341 rs2271111 rs2659585 rs35688737 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:19004829}. Cell membrane {ECO:0000269|PubMed:19004829}. Note=Associated with the edge of the plasma membrane in Caco-2 intestinal epithelial cells spreading on type IV collagen. {ECO:0000269|PubMed:19004829}. |
| Mouse PG classification | NA |
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