| Gene Information | |
|---|---|
| Gene Name | EME1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 570 |
| Protein Names | Crossover junction endonuclease EME1 (EC 3.1.22.-) (MMS4 homolog) (hMMS4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000154920 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q96AY2 |
| Gene Card | EME1 |
| Uniprot ID | Q96AY2 |
| Pfam | PF02732 |
| In ASD | no |
| Allosteric Prediction | no (-0.788588175) |
| Ortholog in Animals | Alpaca_ EME1 ( ortholog_one2one ) Dog_ EME1 ( ortholog_one2one ) GuineaPig_ EME1 ( ortholog_one2one ) Macaque_ EME1 ( ortholog_one2one ) Mouse_ Eme1 ( ortholog_one2one ) Pig_ EME1 ( ortholog_one2one ) Rat_ Eme1 ( ortholog_one2one ) Rabbit_ EME1 ( ortholog_one2one ) |
| Ohnologs | EME2 |
| Paralogs | EME2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002240(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2ZIU (X-ray 2.70A ) 2ZIV (X-ray 2.70A ) 2ZIW (X-ray 2.80A ) 2ZIX (X-ray 3.50A ) 4P0P (X-ray 2.80A ) 4P0Q (X-ray 2.85A ) 4P0R (X-ray 6.50A ) 4P0S (X-ray 6.00A ) |
| DBSNP | rs35248609 rs9896405 rs17714854 rs3760413 rs7222520 rs12450550 |
| Subcellular location [CC] | Nucleus, nucleolus {ECO:0000269|PubMed:14617801}. Note=Recruited to regions of DNA damage in S-phase cells. |
| Mouse PG classification | NA |
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