| Gene Information | |
|---|---|
| Gene Name | EMC10 |
| Organism | Homo sapiens (Human) |
| Gene Length | 262 |
| Protein Names | ER membrane protein complex subunit 10 (Hematopoietic signal peptide-containing membrane domain-containing protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000161671 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q5UCC4 |
| Gene Card | EMC10 |
| Uniprot ID | Q5UCC4 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.323798842) |
| Ortholog in Animals | Alpaca_ EMC10 ( ortholog_one2one ) Dog_ EMC10 ( ortholog_one2one ) GuineaPig_ EMC10 ( ortholog_one2one ) Macaque_ EMC10 ( ortholog_one2one ) Mouse_ Emc10 ( ortholog_one2one ) Pig_ EMC10 ( ortholog_one2one ) Rat_ Emc10 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Present in serum (at protein level). Increased expression seen in the left ventrice after myocardial infarction (at protein level). Expressed in the pituitary gland. Expressed in brain (PubMed:33531666). {ECO:0000269|PubMed:19570817, ECO:0000269|PubMed:20680400, ECO:0000269|PubMed:28931551, ECO:0000269|PubMed:33531666}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.020410(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6WW7 (EM 3.40A ) 6Z3W (EM 6.40A ) 7ADO (EM 3.39A ) 7ADP (EM 3.60A ) |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000305|PubMed:22119785, ECO:0000305|PubMed:32439656, ECO:0000305|PubMed:32459176}; Single-pass type I membrane protein {ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176}.; [Isoform 2]: Secreted {ECO:0000269|PubMed:19570817, ECO:0000269|PubMed:20680400, ECO:0000269|PubMed:28931551}. |
| Mouse PG classification | NA |
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