Gene Information
Gene NameITPR3
OrganismHomo sapiens (Human)
Gene Length2671
Protein NamesInositol 1,4,5-trisphosphate receptor type 3 (IP3 receptor isoform 3) (IP3R 3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor)
Target Nameinositol 1,4,5-trisphosphate receptor
Target TypeNA
Gene Age680 ( ENSG00000096433 )
Evolutionary StageVertebrata
AlphaFoldDBQ14573
Gene CardITPR3
Uniprot IDQ14573
PfamPF08709; PF00520; PF02815; PF08454; PF01365
In ASDno
Allosteric Predictionyes (1.487368831)
Ortholog in AnimalsAlpaca_ ITPR3 ( ortholog_one2one )
Dog_ ITPR3 ( ortholog_one2one )
GuineaPig_ ITPR3 ( ortholog_one2one )
Macaque_ ITPR3 ( ortholog_one2one )
Mouse_ Itpr3 ( ortholog_one2one )
Pig_ ITPR3 ( ortholog_one2one )
Rat_ Itpr3 ( ortholog_one2one )
Rabbit_ ITPR3 ( ortholog_one2one )
OhnologsITPR2, ITPR1
ParalogsRYR2, ITPR2, RYR1, ITPR1, RYR3
TissueNA
Tissue SpecificityExpressed in intestinal crypt and villus epithelial cells.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6DQJ  (EM  3.49A  )  6DQN  (EM  3.33A  )  6DQS  (EM  4.12A  )  6DQV  (EM  3.82A  )  6DQZ  (EM  6.01A  )  6DR0  (EM  4.47A  )  6DR2  (EM  4.33A  )  6DRA  (EM  3.96A  )  6DRC  (EM  3.92A  )  6UQK  (EM  3.77A  )  7T3P  (EM  3.20A  )  7T3Q  (EM  3.30A  )  7T3R  (EM  3.40A  )  7T3T  (EM  3.80A  )  7T3U  (EM  3.70A  ) 
DBSNP rs2229646  rs11963294  rs2229633  rs2296333  rs9461899  rs12528378  rs2229641  rs2229642 
Subcellular location [CC]Endoplasmic reticulum membrane;
Multi-pass membrane protein.
Mouse PG classificationLPG
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