Gene Information
Gene NameELOVL5
OrganismHomo sapiens (Human)
Gene Length299
Protein NamesElongation of very long chain fatty acids protein 5 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL5) (ELOVL fatty acid elongase 5) (ELOVL FA elongase 5) (Fatty acid elongase 1) (hELO1) (Very long chain 3-ketoacyl-CoA synthase 5) (Very long chain 3-oxoacyl-CoA synthase 5)
Target Nameelongation of very long chain fatty acids protein 5
Target TypeNA
Gene Age1714 ( ENSG00000012660 )
Evolutionary StageEukaryota
AlphaFoldDBQ9NYP7
Gene CardELOVL5
Uniprot IDQ9NYP7
PfamPF01151
In ASDno
Allosteric Predictionno (-0.781101085)
Ortholog in AnimalsAlpaca_ ELOVL5 ( ortholog_one2one )
Dog_ ELOVL5 ( ortholog_one2one )
GuineaPig_ ELOVL5 ( ortholog_one2one )
Macaque_ ELOVL5 ( ortholog_one2one )
Mouse_ Elovl5 ( ortholog_one2one )
Pig_ ELOVL5 ( ortholog_one2one )
Rat_ Elovl5 ( ortholog_one2one )
Rabbit_ ELOVL5 ( ortholog_one2one )
OhnologsELOVL2
ParalogsELOVL2, ELOVL4, ELOVL1, ELOVL7, ELOVL3, ELOVL6
TissueNA
Tissue SpecificityUbiquitous. Highly expressed in the adrenal gland and testis. Weakly expressed in prostate, lung and brain. Expressed in the cerebellum. {ECO:0000269|PubMed:10970790, ECO:0000269|PubMed:20937905, ECO:0000269|PubMed:25065913}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs587777671  rs587777670 
Subcellular location [CC]Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03205, ECO:0000269|PubMed:20937905};
Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03205}. Cell projection, dendrite {ECO:0000255|HAMAP-Rule:MF_03205, ECO:0000269|PubMed:25065913}. Note=In Purkinje cells, the protein localizes to the soma and proximal portion of the dendritic tree. {ECO:0000255|HAMAP-Rule:MF_03205, ECO:0000269|PubMed:25065913}.
Mouse PG classificationLPG
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