| Gene Information | |
|---|---|
| Gene Name | SERPINC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 464 |
| Protein Names | Antithrombin-III (ATIII) (Serpin C1) |
| Target Name | antithrombin-iii |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000117601 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P01008 |
| Gene Card | SERPINC1 |
| Uniprot ID | P01008 |
| Pfam | PF00079 |
| In ASD | yes |
| Allosteric Prediction | yes (1.138305413) |
| Ortholog in Animals | Alpaca_ SERPINC1 ( ortholog_one2one ) Dog_ SERPINC1 ( ortholog_one2one ) Macaque_ SERPINC1 ( ortholog_one2one ) Mouse_ Serpinc1 ( ortholog_one2one ) Pig_ SERPINC1 ( ortholog_one2one ) Rat_ Serpinc1 ( ortholog_one2one ) Rabbit_ SERPINC1 ( ortholog_one2one ) |
| Ohnologs | SERPINI2, SERPINE2, SERPINI1 |
| Paralogs | SERPING1, SERPINB7, SERPINF1, SERPINI1, AGT, SERPIND1, SERPINA7, SERPINB8, SERPINA6, SERPINI2, HMSD, SERPINB6, SERPINB1, SERPINA10, SERPINH1, SERPINB13, SERPINA3, SERPINA5, SERPINA9, SERPINA12, SERPINE1, SERPINF2, SERPINA4, SERPINB11, SERPINB5, SERPINB12, SERPINB9, SERPINE3, SERPINB4, SERPINB3, SERPINE2, SERPINA1, SERPINA2, SERPINB10, SERPINA11, SERPINB2 |
| Tissue | liver |
| Tissue Specificity | Found in plasma. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.08(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1ANT (X-ray 3.00A ) 1ATH (X-ray 3.20A ) 1AZX (X-ray 2.90A ) 1BR8 (X-ray 2.90A ) 1DZG (X-ray 2.80A ) 1DZH (X-ray 2.85A ) 1E03 (X-ray 2.90A ) 1E04 (X-ray 2.60A ) 1E05 (X-ray 2.62A ) 1JVQ (X-ray 2.60A ) 1LK6 (X-ray 2.80A ) 1NQ9 (X-ray 2.60A ) 1OYH (X-ray 2.62A ) 1R1L (X-ray 2.70A ) 1SR5 (X-ray 3.10A ) 1T1F (X-ray 2.75A ) 1TB6 (X-ray 2.50A ) 2ANT (X-ray 2.60A ) 2B4X (X-ray 2.80A ) 2B5T (X-ray 2.10A ) 2BEH (X-ray 2.70A ) 2GD4 (X-ray 3.30A ) 2HIJ (X-ray 2.90A ) 2ZNH (X-ray 2.80A ) 3EVJ (X-ray 3.00A ) 3KCG (X-ray 1.70A ) 4EB1 (X-ray 2.80A ) |
| DBSNP | rs387906575 rs2227624 rs121909558 rs892712171 rs28929469 rs121909551 rs121909547 rs121909552 rs121909547 rs147266200 rs907768931 rs121909573 rs121909567 rs1411331203 rs1170430756 rs2227606 rs121909569 rs765445413 rs121909563 rs121909570 rs1425532034 rs1572090114 rs483352854 rs121909571 rs121909572 rs1423630663 rs758087836 rs121909565 rs201541724 rs121909557 rs121909548 rs121909548 rs121909568 rs121909566 rs121909554 rs121909549 rs121909549 rs121909550 rs1572084546 rs121909546 rs1301351856 rs121909555 rs1487411568 rs1188571702 rs1572084448 rs121909564 |
| Subcellular location [CC] | Secreted, extracellular space. |
| Mouse PG classification | HPG |
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