| Gene Information | |
|---|---|
| Gene Name | ELL |
| Organism | Homo sapiens (Human) |
| Gene Length | 621 |
| Protein Names | RNA polymerase II elongation factor ELL (Eleven-nineteen lysine-rich leukemia protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000105656 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P55199 |
| Gene Card | ELL |
| Uniprot ID | P55199 |
| Pfam | PF10390; PF07303 |
| In ASD | no |
| Allosteric Prediction | no (-0.288939945) |
| Ortholog in Animals | Alpaca_ ELL ( ortholog_one2one ) Dog_ ISYNA1 ( ortholog_one2one ) GuineaPig_ ELL ( ortholog_one2one ) Macaque_ ELL ( ortholog_one2one ) Mouse_ Ell ( ortholog_one2one ) Pig_ ELL ( ortholog_one2one ) Rat_ Ell ( ortholog_one2one ) |
| Ohnologs | ELL2 |
| Paralogs | OCLN, OCEL1, ELL2, ELL3, MARVELD2 |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues tested. Highest levels found in placenta, skeletal muscle, testis and peripheral blood leukocytes. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2DOA (NMR - ) |
| DBSNP | rs2303694 rs35245196 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:11418481, ECO:0000269|PubMed:12446457}. Nucleus speckle {ECO:0000269|PubMed:11418481, ECO:0000269|PubMed:12446457}. Nucleus, Cajal body {ECO:0000269|PubMed:12686606, ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. Note=Colocalizes with EAF2 to nuclear speckles (PubMed:12446457). Colocalizes with coilin in subnuclear cajal and histone locus bodies (PubMed:12686606). Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes(PubMed:23932780). {ECO:0000269|PubMed:12446457, ECO:0000269|PubMed:12686606, ECO:0000269|PubMed:23932780}. |
| Mouse PG classification | NA |
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