| Gene Information | |
|---|---|
| Gene Name | ELF5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 265 |
| Protein Names | ETS-related transcription factor Elf-5 (E74-like factor 5) (Epithelium-restricted ESE-1-related Ets factor) (Epithelium-specific Ets transcription factor 2) (ESE-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000135374 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9UKW6 |
| Gene Card | ELF5 |
| Uniprot ID | Q9UKW6 |
| Pfam | PF00178; PF02198 |
| In ASD | no |
| Allosteric Prediction | no (-1.169413973) |
| Ortholog in Animals | Alpaca_ ELF5 ( ortholog_one2one ) Dog_ ELF5 ( ortholog_one2one ) GuineaPig_ ELF5 ( ortholog_one2one ) Macaque_ ELF5 ( ortholog_one2one ) Mouse_ Elf5 ( ortholog_one2one ) Pig_ ELF5 ( ortholog_one2one ) Rat_ Elf5 ( ortholog_one2one ) Rabbit_ ELF5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ELK1, ETV6, ERG, ERF, ETV4, ETV7, ELF4, ELF3, EHF, ETV2, ETV3L, ETS2, FLI1, GABPA, ETV5, ETV1, ETV3, ELK3, ETS1, ELF2, SPI1, ELK4, ELF1, SPIB, FEV, SPIC, ERFL, SPDEF |
| Tissue | salivary.gland, parotid.gland, seminal.vesicle, submandibular.gland, vas.deferens, minor.salivary.gland |
| Tissue Specificity | Expressed exclusively in tissues with a high content of epithelial cells. Highly expressed in salivary gland, mammary gland, kidney and prostate. Weakly expressed in placenta and lung. Isoform 1 and isoform 2 are differentially expressed in different tissues. In the kidney, only isoform 1 was expressed, while prostate expressed both isoforms, with levels of isoform 2 being higher. Expression is up-regulated during keratinocyte differentiation. Several epithelial carcinoma cell lines showed lack of expression. {ECO:0000269|PubMed:10506207, ECO:0000269|PubMed:9840936}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1WWX (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}. |
| Mouse PG classification | NA |
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