| Gene Information | |
|---|---|
| Gene Name | ELF3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 371 |
| Protein Names | ETS-related transcription factor Elf-3 (E74-like factor 3) (Epithelial-restricted with serine box) (Epithelium-restricted Ets protein ESX) (Epithelium-specific Ets transcription factor 1) (ESE-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000163435 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P78545 |
| Gene Card | ELF3 |
| Uniprot ID | P78545 |
| Pfam | PF00178; PF02198 |
| In ASD | no |
| Allosteric Prediction | no (-0.163930762) |
| Ortholog in Animals | Alpaca_ ELF3 ( ortholog_one2one ) Dog_ ELF3 ( ortholog_one2one ) GuineaPig_ ELF3 ( ortholog_one2one ) Macaque_ ELF3 ( ortholog_one2one ) Mouse_ Elf3 ( ortholog_one2one ) Pig_ ELF3 ( ortholog_one2one ) Rat_ Elf3 ( ortholog_one2one ) Rabbit_ ELF3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ELK1, ETV6, ERG, ERF, ETV4, ETV7, ELF4, EHF, ETV2, ETV3L, ETS2, FLI1, GABPA, ETV5, ETV1, ELF5, ETV3, ELK3, ETS1, ELF2, SPI1, ELK4, ELF1, SPIB, FEV, SPIC, ERFL, SPDEF |
| Tissue | NA |
| Tissue Specificity | Expressed exclusively in tissues containing a high content of terminally differentiated epithelial cells including mammary gland, colon, trachea, kidney, prostate, uterus, stomach and skin. {ECO:0000269|PubMed:9129154, ECO:0000269|PubMed:9234700, ECO:0000269|PubMed:9336459, ECO:0000269|PubMed:9395241}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2E8P (NMR - ) |
| DBSNP | rs1135542 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:10391676, ECO:0000269|PubMed:15169914, ECO:0000269|PubMed:17060315}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237, ECO:0000269|PubMed:10391676, ECO:0000269|PubMed:15169914, ECO:0000269|PubMed:17060315}. Note=Localizes to the cytoplasm where it has been shown to transform MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A and MCF-12A via a transcription-dependent mechanism. {ECO:0000269|PubMed:10391676, ECO:0000269|PubMed:15169914, ECO:0000269|PubMed:17060315}. |
| Mouse PG classification | NA |
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