Gene Information
Gene NameELA2
OrganismHomo sapiens (Human)
Gene Length267
Protein NamesNeutrophil elastase (EC 3.4.21.37) (Bone marrow serine protease) (Elastase-2) (Human leukocyte elastase) (HLE) (Medullasin) (PMN elastase)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBP08246
Gene CardELANE
Uniprot IDP08246
PfamPF00089
In ASDyes
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityBone marrow cells. Neutrophil (PubMed:10947984). {ECO:0000269|PubMed:10947984}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.005990(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1B0F  (X-ray  3.00A  )  1H1B  (X-ray  2.00A  )  1HNE  (X-ray  1.84A  )  1PPF  (X-ray  1.80A  )  1PPG  (X-ray  2.30A  )  2RG3  (X-ray  1.80A  )  2Z7F  (X-ray  1.70A  )  3Q76  (X-ray  1.86A  )  3Q77  (X-ray  2.00A  )  4NZL  (X-ray  1.85A  )  4WVP  (X-ray  1.63A  )  5A09  (X-ray  1.81A  )  5A0A  (X-ray  1.78A  )  5A0B  (X-ray  2.23A  )  5A0C  (X-ray  2.10A  )  5A8X  (X-ray  2.23A  )  5A8Y  (X-ray  1.90A  )  5A8Z  (X-ray  2.00A  )  5ABW  (X-ray  1.60A  )  6E69  (X-ray  2.33A  )  6F5M  (X-ray  2.70A  )  6SMA  (X-ray  2.59A  )  7CBK  (X-ray  2.70A  )  7WHU  (X-ray  2.89A  ) 
DBSNP rs1396230082  rs878855320  rs878855319  rs1131691882  rs1057520110  rs137854447  rs878855315  rs28931611  rs1064793108  rs267606781  rs267606781  rs137854449  rs137854449  rs745455816  rs1382122842  rs1131691520  rs377698556  rs137854450  rs201729066  rs774457980  rs137854448  rs200993994  rs57246956  rs57246956  rs201788817  rs201139487  rs1555710077  rs137854446  rs137854451  rs17216656  rs137854445  rs17216663  rs17216670 
Subcellular location [CC]Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:10947984}. Note=Localized in phagolysosomes following ingestion of E.coli by neutrophils. {ECO:0000269|PubMed:10947984}.
Mouse PG classificationNA
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