| Gene Information | |
|---|---|
| Gene Name | EIF6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 245 |
| Protein Names | Eukaryotic translation initiation factor 6 (eIF-6) (B(2)GCN homolog) (B4 integrin interactor) (CAB) (p27(BBP)) |
| Target Name | eukaryotic translation initiation factor 6 |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000242372 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | P56537 |
| Gene Card | EIF6 |
| Uniprot ID | P56537 |
| Pfam | PF01912 |
| In ASD | no |
| Allosteric Prediction | no (-0.069058018) |
| Ortholog in Animals | Alpaca_ EIF6 ( ortholog_one2one ) Dog_ EIF6 ( ortholog_one2one ) GuineaPig_ EIF6 ( ortholog_one2one ) Macaque_ EIF6 ( ortholog_one2one ) Mouse_ Eif6 ( ortholog_one2one ) Pig_ EIF6 ( ortholog_one2one ) Rat_ Eif6 ( ortholog_one2many ) Rat_ Eif6-ps1 ( ortholog_one2many ) Rabbit_ EIF6 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at very high levels in colon carcinoma with lower levels in normal colon and ileum and lowest levels in kidney and muscle (at protein level). {ECO:0000269|PubMed:11290417}. |
| Pharmacological Animal Models | 0.140091(Chimpanzee);0.068656(Mouse);0.002575(Rat);0.056246(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6LQM (EM 3.09A ) 6LSR (EM 3.13A ) 6LSS (EM 3.23A ) 6LU8 (EM 3.13A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm. Nucleus, nucleolus. Note=Shuttles between cytoplasm and nucleus/nucleolus. |
| Mouse PG classification | NA |
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