| Gene Information | |
|---|---|
| Gene Name | EIF5A2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 153 |
| Protein Names | Eukaryotic translation initiation factor 5A-2 (eIF-5A-2) (eIF-5A2) (Eukaryotic initiation factor 5A isoform 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000163577 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | Q9GZV4 |
| Gene Card | EIF5A2 |
| Uniprot ID | Q9GZV4 |
| Pfam | PF01287 |
| In ASD | no |
| Allosteric Prediction | no (-0.974047146) |
| Ortholog in Animals | Alpaca_ EIF5A2 ( ortholog_one2one ) Dog_ EIF5A2 ( ortholog_one2one ) GuineaPig_ EIF5A2 ( ortholog_one2one ) Macaque_ EIF5A2 ( ortholog_one2one ) Mouse_ Eif5a2 ( ortholog_one2one ) Pig_ EIF5A2 ( ortholog_one2one ) Rat_ Eif5a2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | EIF5AL1, EIF5A |
| Tissue | NA |
| Tissue Specificity | Expressed in ovarian and colorectal cancer cell lines (at protein level). Highly expressed in testis. Overexpressed in some cancer cells. {ECO:0000269|PubMed:11161802, ECO:0000269|PubMed:16519677}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001323(Rat);0.006452(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs776545602 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus, nuclear pore complex {ECO:0000250}. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions. {ECO:0000250}. |
| Mouse PG classification | NA |
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