Gene Information
Gene NameEIF5A
OrganismHomo sapiens (Human)
Gene Length154
Protein NamesEukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (Rev-binding factor) (eIF-4D)
Target NameNA
Target TypeNA
Gene Age>4290 ( ENSG00000132507 )
3 ( ENSG00000288145 )
Evolutionary StageEuk_Archaea
AlphaFoldDBP63241
Gene CardEIF5A
Uniprot IDP63241
PfamPF01287
In ASDno
Allosteric Predictionno (-0.751635452)
Ortholog in AnimalsAlpaca_ EIF5A ( ortholog_one2one )
Dog_ EIF5A ( ortholog_one2many )
Mouse_ Eif5a ( ortholog_one2many )
OhnologsNA
ParalogsEIF5AL1, EIF5A2
TissueNA
Tissue SpecificityExpressed in umbilical vein endothelial cells and several cancer cell lines (at protein level). {ECO:0000269|PubMed:16519677}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3CPF  (X-ray  2.50A  )  5DLQ  (X-ray  3.20A  ) 
DBSNP NA 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:10944119, ECO:0000269|PubMed:17187778, ECO:0000269|PubMed:19379712, ECO:0000269|PubMed:27306458, ECO:0000269|PubMed:8660923}. Nucleus {ECO:0000269|PubMed:10944119, ECO:0000269|PubMed:17187778, ECO:0000269|PubMed:19379712, ECO:0000269|PubMed:27306458, ECO:0000269|PubMed:8253832}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:8660923};
Peripheral membrane protein {ECO:0000269|PubMed:8660923};
Cytoplasmic side {ECO:0000269|PubMed:8660923}. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions (PubMed:19379712, PubMed:27306458). Nuclear export of hypusinated protein is mediated by XPO4 (PubMed:10944119, PubMed:27306458). {ECO:0000269|PubMed:10944119, ECO:0000269|PubMed:19379712, ECO:0000269|PubMed:27306458}.
Mouse PG classificationNA
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