| Gene Information | |
|---|---|
| Gene Name | EIF4H |
| Organism | Homo sapiens (Human) |
| Gene Length | 248 |
| Protein Names | Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000106682 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q15056 |
| Gene Card | EIF4H |
| Uniprot ID | Q15056 |
| Pfam | PF00076 |
| In ASD | no |
| Allosteric Prediction | no (-0.678462082) |
| Ortholog in Animals | Alpaca_ EIF4H ( ortholog_one2one ) Dog_ EIF4H ( ortholog_one2one ) GuineaPig_ EIF4H ( ortholog_one2one ) Macaque_ EIF4H ( ortholog_one2one ) Mouse_ Eif4h ( ortholog_one2one ) Pig_ EIF4H ( ortholog_one2one ) Rat_ Eif4h ( ortholog_one2one ) Rabbit_ EIF4H ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | EIF4B |
| Tissue | NA |
| Tissue Specificity | The short isoform is the predominant isoform and is expressed alone in liver and skeletal muscle. Both isoforms are expressed in fibroblast, spleen, testis and bone marrow. Levels are high in lung and pancreas and low in heart, frontal cortex and kidney. {ECO:0000269|PubMed:11003705, ECO:0000269|PubMed:8812460}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.014286(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, perinuclear region {ECO:0000250}. |
| Mouse PG classification | NA |
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