| Gene Information | |
|---|---|
| Gene Name | PTCHD3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 954 |
| Protein Names | Patched domain-containing protein 3 (Patched-related protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000182077 ) 3 ( ENSG00000276595 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q3KNS1 |
| Gene Card | PTCHD3 |
| Uniprot ID | Q3KNS1 |
| Pfam | PF02460 |
| In ASD | no |
| Allosteric Prediction | no (-1.014575114) |
| Ortholog in Animals | Alpaca_ PTCHD3 ( ortholog_one2one ) GuineaPig_ PTCHD3 ( ortholog_one2one ) Macaque_ PTCHD3 ( ortholog_one2one ) Mouse_ Ptchd3 ( ortholog_one2one ) Pig_ PTCHD3 ( ortholog_one2one ) Rat_ Ptchd3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DISP1, DISP3, SCAP, NPC1, PTCHD1, PTCH2, PTCHD4, NPC1L1, DISP2, PTCH1 |
| Tissue | NA |
| Tissue Specificity | Expressed in germ cells of the testis (at protein level) (PubMed:17904097). Detected in blood lymph, colon, small intestine, ovary, testis, prostate, thymus and spleen with highest levels in testis (PubMed:21439084). {ECO:0000269|PubMed:17904097, ECO:0000269|PubMed:21439084}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs12098477 rs6482626 rs12098562 rs2152099 rs2484180 rs2429485 rs2505327 rs1638630 |
| Subcellular location [CC] | Cell projection, cilium, flagellum membrane {ECO:0000269|PubMed:17904097}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21439084}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the midpiece of the sperm tail. {ECO:0000269|PubMed:17904097}. |
| Mouse PG classification | NA |
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