| Gene Information | |
|---|---|
| Gene Name | EIF4G1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1599 |
| Protein Names | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000114867 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q04637 |
| Gene Card | EIF4G1 |
| Uniprot ID | Q04637 |
| Pfam | PF02847; PF02854; PF02020 |
| In ASD | no |
| Allosteric Prediction | yes (0.357091301) |
| Ortholog in Animals | Alpaca_ EIF4G1 ( ortholog_one2one ) Dog_ EIF4G1 ( ortholog_one2one ) GuineaPig_ EIF4G1 ( ortholog_one2one ) Macaque_ EIF4G1 ( ortholog_one2one ) Mouse_ Eif4g1 ( ortholog_one2one ) Pig_ EIF4G1 ( ortholog_one2one ) Rat_ Eif4g1 ( ortholog_one2one ) Rabbit_ EIF4G1 ( ortholog_one2one ) |
| Ohnologs | EIF4G3 |
| Paralogs | EIF4G3, EIF4G2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001472(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1LJ2 (X-ray 2.38A ) 1UG3 (X-ray 2.24A ) 2W97 (X-ray 2.29A ) 4AZA (X-ray 2.16A ) 4F02 (X-ray 2.00A ) 5EHC (X-ray 2.40A ) 5EI3 (X-ray 1.71A ) 5EIR (X-ray 2.69A ) 5T46 (X-ray 1.53A ) 5ZK5 (X-ray 2.25A ) 6ZMW (EM 3.70A ) |
| DBSNP | rs113810947 rs13319149 rs34838305 rs16858632 rs2178403 rs111290936 rs112019125 rs754755344 rs62287499 rs111500185 rs113169049 rs113388242 rs112176450 rs35629949 rs2230570 rs73053766 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17984221}. Nucleus {ECO:0000269|PubMed:17984221}. Cytoplasm, Stress granule {ECO:0000269|PubMed:22872150}. |
| Mouse PG classification | NA |
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