| Gene Information | |
|---|---|
| Gene Name | EIF4A3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 411 |
| Protein Names | Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Eukaryotic translation initiation factor 4A isoform 3) (Nuclear matrix protein 265) (NMP 265) (hNMP 265) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000141543 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P38919 |
| Gene Card | EIF4A3 |
| Uniprot ID | P38919 |
| Pfam | PF00270; PF00271 |
| In ASD | yes |
| Allosteric Prediction | yes (0.009135362) |
| Ortholog in Animals | Alpaca_ EIF4A3 ( ortholog_one2one ) Dog_ EIF4A3 ( ortholog_one2one ) GuineaPig_ EIF4A3 ( ortholog_one2one ) Macaque_ EIF4A3 ( ortholog_one2one ) Mouse_ Eif4a3l2 ( ortholog_one2many ) Mouse_ Eif4a3 ( ortholog_one2many ) Mouse_ Eif4a3l1 ( ortholog_one2many ) Pig_ EIF4A3 ( ortholog_one2one ) Rat_ Eif4a3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DDX28, DDX42, DDX25, DDX47, DDX49, DDX20, DDX50, DDX41, DDX24, TDRD12, DDX5, DDX52, DDX56, DDX3X, DDX3Y, DDX59, DDX39B, DDX23, DDX54, DDX10, DDX19A, DDX19B, EIF4A1, DDX6, DDX39A, DDX55, DDX18, DDX21, DDX4, DDX1, DDX53, DDX17, DDX31, DDX51, DDX43, EIF4A2, DDX27, DDX46 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:10623621}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2HXY (X-ray 3.30A ) 2HYI (X-ray 2.30A ) 2J0Q (X-ray 3.20A ) 2J0S (X-ray 2.21A ) 2J0U (X-ray 3.00A ) 2XB2 (X-ray 3.40A ) 3EX7 (X-ray 2.30A ) 4C9B (X-ray 2.00A ) 5MQF (EM 5.90A ) 5XJC (EM 3.60A ) 5YZG (EM 4.10A ) 6ICZ (EM 3.00A ) 6QDV (EM 3.30A ) 6YVH (X-ray 3.19A ) 7A5P (EM 5.00A ) 7W59 (EM 3.60A ) 7W5A (EM 3.60A ) 7W5B (EM 4.30A ) |
| DBSNP | rs587777204 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10623621, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:22961380, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961}. Nucleus speckle {ECO:0000269|PubMed:10623621}. Cytoplasm {ECO:0000250|UniProtKB:Q3B8Q2}. Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Detected in dendritic layer as well as the nuclear and cytoplasmic (somatic) compartments of neurons. Colocalizes with STAU1 and FMR1 in dendrites (By similarity). {ECO:0000250|UniProtKB:Q3B8Q2}. |
| Mouse PG classification | NA |
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