| Gene Information | |
|---|---|
| Gene Name | EIF3E |
| Organism | Homo sapiens (Human) |
| Gene Length | 445 |
| Protein Names | Eukaryotic translation initiation factor 3 subunit E (eIF3e) (Eukaryotic translation initiation factor 3 subunit 6) (Viral integration site protein INT-6 homolog) (eIF-3 p48) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000104408 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P60228 |
| Gene Card | EIF3E |
| Uniprot ID | P60228 |
| Pfam | PF09440; PF01399 |
| In ASD | no |
| Allosteric Prediction | no (-0.359492929) |
| Ortholog in Animals | Alpaca_ EIF3E ( ortholog_one2one ) Dog_ EIF3E ( ortholog_one2one ) Macaque_ EIF3E ( ortholog_one2one ) Mouse_ Eif3e ( ortholog_one2one ) Pig_ EIF3E ( ortholog_one2one ) Rat_ Eif3el1 ( ortholog_one2many ) Rabbit_ EIF3E ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. Expressed at highest levels in appendix, lymph, pancreas, skeletal muscle, spleen and thymus. {ECO:0000269|PubMed:8688078, ECO:0000269|PubMed:9295280}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.213838(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3J8B (EM - ) 3J8C (EM - ) 6FEC (EM 6.30A ) 6YBD (EM 3.30A ) 6ZMW (EM 3.70A ) 6ZON (EM 3.00A ) 6ZP4 (EM 2.90A ) 6ZVJ (EM 3.80A ) 7A09 (EM 3.50A ) 7QP6 (EM 4.70A ) 7QP7 (EM 3.70A ) |
| DBSNP | rs17856554 |
| Subcellular location [CC] | Cytoplasm. Nucleus, PML body. |
| Mouse PG classification | NA |
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