Gene Information
Gene NameEIF2S1
OrganismHomo sapiens (Human)
Gene Length315
Protein NamesEukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000134001 )
Evolutionary StageEuk_Archaea
AlphaFoldDBP05198
Gene CardEIF2S1
Uniprot IDP05198
PfamPF07541; PF00575
In ASDno
Allosteric Predictionyes (0.011103521)
Ortholog in AnimalsAlpaca_ EIF2S1 ( ortholog_one2one )
Dog_ EIF2S1 ( ortholog_one2one )
GuineaPig_ EIF2S1 ( ortholog_one2one )
Macaque_ EIF2S1 ( ortholog_one2one )
Mouse_ Eif2s1 ( ortholog_one2one )
Pig_ EIF2S1 ( ortholog_one2one )
Rat_ Eif2s1 ( ortholog_one2one )
Rabbit_ EIF2S1 ( ortholog_one2one )
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.072482(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1KL9  (X-ray  1.90A  )  1Q8K  (NMR  -  )  6K71  (EM  4.30A  )  6K72  (EM  4.60A  )  6O81  (EM  3.21A  )  6O85  (EM  3.03A  )  6O9Z  (EM  3.03A  )  6YBV  (EM  3.80A  )  6ZMW  (EM  3.70A  )  6ZP4  (EM  2.90A  )  7A09  (EM  3.50A  )  7D43  (EM  4.30A  )  7D44  (EM  4.00A  )  7D45  (EM  3.80A  )  7F66  (EM  2.76A  )  7F67  (EM  3.59A  )  7NZM  (EM  3.96A  )  7QP6  (EM  4.70A  )  7QP7  (EM  3.70A  )  7SYR  (EM  3.60A  )  7SYS  (EM  3.50A  ) 
DBSNP NA 
Subcellular location [CC]Cytoplasm, Stress granule {ECO:0000250|UniProtKB:Q6ZWX6}. Note=Colocalizes with NANOS3 in the stress granules. {ECO:0000250|UniProtKB:Q6ZWX6}.
Mouse PG classificationNA
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