Gene Information
Gene NameEIF2C2
OrganismHomo sapiens (Human)
Gene Length859
Protein NamesProtein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBQ9UKV8
Gene CardAGO2
Uniprot IDQ9UKV8
PfamPF08699; PF16488; PF16487; PF16486; PF02170; PF02171
In ASDyes
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3LUC  (X-ray  1.69A  3LUD  (X-ray  2.10A  3LUG  (X-ray  1.85A  3LUH  (X-ray  2.00A  3LUJ  (X-ray  1.80A  3LUK  (X-ray  1.70A  3QX8  (X-ray  2.30A  3QX9  (X-ray  2.00A  4F3T  (X-ray  2.25A  4OLA  (X-ray  2.30A  4OLB  (X-ray  2.90A  4W5N  (X-ray  2.90A  4W5O  (X-ray  1.80A  4W5Q  (X-ray  3.10A  4W5R  (X-ray  2.50A  4W5T  (X-ray  2.50A  4Z4C  (X-ray  2.30A  4Z4D  (X-ray  1.60A  4Z4E  (X-ray  1.80A  4Z4F  (X-ray  2.80A  4Z4G  (X-ray  2.70A  4Z4H  (X-ray  2.50A  4Z4I  (X-ray  2.80A  5JS1  (X-ray  2.50A  5JS2  (X-ray  2.95A  5KI6  (X-ray  2.15A  5T7B  (X-ray  2.53A  5WEA  (X-ray  3.12A  6CBD  (X-ray  2.20A  6MDZ  (X-ray  3.40A  6MFN  (X-ray  2.50A  6MFR  (X-ray  3.60A  6N4O  (X-ray  2.90A  6NIT  (X-ray  3.80A  6RA4  (X-ray  1.90A  7C6B  (X-ray  1.70A  7D7U  (X-ray  2.00A  7KI3  (X-ray  3.00A 
DBSNP NA 
Subcellular location [CC]Cytoplasm, P-body {ECO:0000269|PubMed:23125361, ECO:0000269|PubMed:23603119, ECO:0000269|PubMed:33199684}. Nucleus {ECO:0000269|PubMed:23125361}. Note=Translational repression of mRNAs results in their recruitment to P-bodies. Translocation to the nucleus requires IMP8.
Mouse PG classificationNA
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