Gene Information
Gene NameEHD1
OrganismHomo sapiens (Human)
Gene Length534
Protein NamesEH domain-containing protein 1 (PAST homolog 1) (hPAST1) (Testilin)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000110047 )
Evolutionary StageEukaryota
AlphaFoldDBQ9H4M9
Gene CardEHD1
Uniprot IDQ9H4M9
PfamPF18150; PF00350; PF12763; PF16880
In ASDno
Allosteric Predictionno (-0.747404625)
Ortholog in AnimalsAlpaca_ EHD1 ( ortholog_one2one )
Dog_ EHD1 ( ortholog_one2one )
GuineaPig_ EHD1 ( ortholog_one2one )
Macaque_ EHD1 ( ortholog_one2one )
Mouse_ Ehd1 ( ortholog_one2one )
Pig_ EHD1 ( ortholog_one2one )
Rat_ Ehd1 ( ortholog_one2one )
Rabbit_ EHD1 ( ortholog_one2one )
OhnologsEHD2, EHD4, EHD3
ParalogsEPS15L1, REPS2, ITSN2, SRL, EPS15, ITSN1, EHD2, EHD4, EHD3, REPS1
TissueNA
Tissue SpecificityHighly expressed in testis. {ECO:0000269|PubMed:10395801}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2JQ6  (NMR  -  )  2KFF  (NMR  -  )  2KFG  (NMR  -  )  2KFH  (NMR  -  )  2KSP  (NMR  -  ) 
DBSNP NA 
Subcellular location [CC]Recycling endosome membrane {ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:23596323};
Peripheral membrane protein {ECO:0000305};
Cytoplasmic side {ECO:0000305}. Early endosome membrane {ECO:0000269|PubMed:15020713};
Peripheral membrane protein {ECO:0000305};
Cytoplasmic side {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:Q9WVK4};
Peripheral membrane protein {ECO:0000305};
Cytoplasmic side {ECO:0000305}. Cell projection, cilium membrane {ECO:0000269|PubMed:25686250};
Peripheral membrane protein {ECO:0000305};
Cytoplasmic side {ECO:0000305}. Note=Preferentially associates with tubular recycling endosomes (PubMed:15020713, PubMed:17233914, PubMed:19864458, PubMed:23596323). Colocalizes with FER1L5 at plasma membrane in myoblasts and myotubes (By similarity). Localizes to the ciliary pocket from where the cilium protrudes (PubMed:25686250). Colocalizes with BACE1 in tubulovesicular cytoplasmic membranes. Colocalizes with BACE1 and APP amyloid beta proteins in hippocampal mossy fiber terminals (By similarity). {ECO:0000250|UniProtKB:Q9WVK4, ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:25686250}.
Mouse PG classificationNA
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