| Gene Information | |
|---|---|
| Gene Name | EGR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 543 |
| Protein Names | Early growth response protein 1 (EGR-1) (AT225) (Nerve growth factor-induced protein A) (NGFI-A) (Transcription factor ETR103) (Transcription factor Zif268) (Zinc finger protein 225) (Zinc finger protein Krox-24) |
| Target Name | early growth response protein 1 |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000120738 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P18146 |
| Gene Card | EGR1 |
| Uniprot ID | P18146 |
| Pfam | PF11914; PF11928; PF00096 |
| In ASD | no |
| Allosteric Prediction | yes (0.437420027) |
| Ortholog in Animals | Alpaca_ EGR1 ( ortholog_one2one ) Dog_ EGR1 ( ortholog_one2one ) GuineaPig_ EGR1 ( ortholog_one2one ) Macaque_ EGR1 ( ortholog_one2one ) Mouse_ Egr1 ( ortholog_one2one ) Pig_ EGR1 ( ortholog_one2one ) Rat_ Egr1 ( ortholog_one2one ) Rabbit_ EGR1 ( ortholog_one2one ) |
| Ohnologs | EGR2, EGR3 |
| Paralogs | EGR2, EGR3, WT1, EGR4 |
| Tissue | NA |
| Tissue Specificity | Detected in neutrophils (at protein level). {ECO:0000269|PubMed:20363028}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002101(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4R2A (X-ray 1.59A ) 4R2C (X-ray 1.89A ) 4R2D (X-ray 2.09A ) 4X9J (X-ray 1.41A ) 5N14 (NMR - ) |
| DBSNP | rs13181973 rs28365166 rs28365164 rs28365165 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:20363028}. Cytoplasm {ECO:0000269|PubMed:20363028}. |
| Mouse PG classification | NA |
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