| Gene Information | |
|---|---|
| Gene Name | LMOD2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 547 |
| Protein Names | Leiomodin-2 (Cardiac leiomodin) (C-LMOD) (Leiomodin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000170807 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q6P5Q4 |
| Gene Card | LMOD2 |
| Uniprot ID | Q6P5Q4 |
| Pfam | PF03250 |
| In ASD | no |
| Allosteric Prediction | no (-1.247026294) |
| Ortholog in Animals | Alpaca_ LMOD2 ( ortholog_one2one ) Dog_ LMOD2 ( ortholog_one2one ) GuineaPig_ LMOD2 ( ortholog_one2one ) Macaque_ LMOD2 ( ortholog_one2one ) Mouse_ Lmod2 ( ortholog_one2one ) Pig_ LMOD2 ( ortholog_one2one ) Rat_ Lmod2 ( ortholog_one2one ) Rabbit_ LMOD2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LMOD3, TMOD1, LMOD1, TMOD2, TMOD3, TMOD4 |
| Tissue | heart, skeletal.muscle, artery, left.atrium, left.ventricle, mitral.valve, pulmonary.valve, tongue, atrium |
| Tissue Specificity | Specifically expressed in heart and skeletal muscles, with higher levels in heart (at protein level). Not expressed in other tissues. {ECO:0000269|PubMed:11318603, ECO:0000269|PubMed:25250574}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 4RWT (X-ray 2.98A ) 5WFN (X-ray 3.00A ) 6UT2 (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, myofibril, sarcomere {ECO:0000269|PubMed:18403713, ECO:0000269|PubMed:20685966, ECO:0000269|PubMed:26370058}. Cytoplasm, myofibril {ECO:0000269|PubMed:20685966}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000269|PubMed:18403713, ECO:0000269|PubMed:20685966}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:26370058}. Note=Colocalizes with actin filaments in sarcomeres. Detected close to the M line. {ECO:0000269|PubMed:18403713, ECO:0000269|PubMed:20685966, ECO:0000269|PubMed:26370058}. |
| Mouse PG classification | NA |
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