| Gene Information | |
|---|---|
| Gene Name | SH3BP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 701 |
| Protein Names | SH3 domain-binding protein 1 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000100092 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y3L3 |
| Gene Card | SH3BP1 |
| Uniprot ID | Q9Y3L3 |
| Pfam | PF03114; PF00620 |
| In ASD | no |
| Allosteric Prediction | no (-1.000046076) |
| Ortholog in Animals | Alpaca_ SH3BP1 ( ortholog_one2one ) Dog_ SH3BP1 ( ortholog_one2one ) GuineaPig_ SH3BP1 ( ortholog_one2one ) Macaque_ SH3BP1 ( ortholog_one2one ) Mouse_ Sh3bp1 ( ortholog_one2one ) Pig_ SH3BP1 ( ortholog_one2one ) Rat_ Sh3bp1 ( ortholog_one2one ) Rabbit_ SH3BP1 ( ortholog_one2one ) |
| Ohnologs | ARHGAP44, ARHGAP17 |
| Paralogs | ARHGAP44, ARHGAP17 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4J9D (X-ray 1.50A ) 4J9F (X-ray 1.09A ) |
| DBSNP | rs929038 rs2269548 |
| Subcellular location [CC] | Cell projection {ECO:0000269|PubMed:21658605, ECO:0000269|PubMed:24841563}. Cell junction, tight junction {ECO:0000269|PubMed:22891260}. Cell junction, adherens junction {ECO:0000269|PubMed:22891260}. Cell projection, phagocytic cup {ECO:0000269|PubMed:26465210}. Nucleus {ECO:0000269|PubMed:22891260}. Cytoplasm, cytosol {ECO:0000269|PubMed:22891260}. Note=Localizes at the leading edge of migrating cells (PubMed:21658605, PubMed:24841563). Accumulation at forming phagocytic cups is PI3 kinase/PI3K-dependent and is specific for sites of large particles engagement and their phosphatidylinositol 3,4,5-triphosphate membrane content (PubMed:26465210). {ECO:0000269|PubMed:21658605, ECO:0000269|PubMed:24841563, ECO:0000269|PubMed:26465210}. |
| Mouse PG classification | NA |
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