| Gene Information | |
|---|---|
| Gene Name | HUS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 280 |
| Protein Names | Checkpoint protein HUS1 (hHUS1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000136273 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O60921 |
| Gene Card | HUS1 |
| Uniprot ID | O60921 |
| Pfam | PF04005 |
| In ASD | no |
| Allosteric Prediction | no (-0.131015771) |
| Ortholog in Animals | Alpaca_ HUS1 ( ortholog_one2one ) Dog_ HUS1 ( ortholog_one2many ) GuineaPig_ HUS1 ( ortholog_one2one ) Mouse_ Hus1 ( ortholog_one2one ) Pig_ HUS1 ( ortholog_one2one ) Rat_ Hus1 ( ortholog_one2one ) Rabbit_ HUS1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HUS1B |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:10777662}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.847407(Rat);0.109668(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3A1J (X-ray 2.50A ) 3G65 (X-ray 2.90A ) 3GGR (X-ray 3.20A ) 6J8Y (X-ray 2.40A ) 7Z6H (EM 3.59A ) |
| DBSNP | rs2307261 rs2307254 rs3176588 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10846170, ECO:0000269|PubMed:11077446}. Cytoplasm, cytosol {ECO:0000269|PubMed:11077446}. Note=In discrete nuclear foci upon DNA damage. According to PubMed:11077446, localized also in the cytoplasm. DNA damage induces its nuclear translocation. Shuttles between the nucleus and the cytoplasm. {ECO:0000269|PubMed:11077446}. |
| Mouse PG classification | NA |
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