| Gene Information | |
|---|---|
| Gene Name | MAPK4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 587 |
| Protein Names | Mitogen-activated protein kinase 4 (MAP kinase 4) (MAPK 4) (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63-MAPK) |
| Target Name | extracellular signal-regulated kinase (erk) |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000141639 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P31152 |
| Gene Card | MAPK4 |
| Uniprot ID | P31152 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | no (-0.361736227) |
| Ortholog in Animals | Alpaca_ MAPK4 ( ortholog_one2one ) Dog_ MAPK4 ( ortholog_one2one ) GuineaPig_ MAPK4 ( ortholog_one2one ) Macaque_ MAPK4 ( ortholog_one2one ) Mouse_ Mapk4 ( ortholog_one2one ) Rat_ Mapk4 ( ortholog_one2one ) Rabbit_ MAPK4 ( ortholog_one2one ) |
| Ohnologs | MAPK6 |
| Paralogs | MAPK8, MAPK10, MAPK1, MAPK6, MAPK12, MAPK13, SRPK1, SRPK3, NLK, MAPK14, MAPK3, MOK, MAPK11, MAK, MAPK15, MAPK7, SRPK2, MAPK9, CILK1 |
| Tissue | adrenal.gland, cerebral.cortex, heart |
| Tissue Specificity | High expression in heart and brain. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs3752087 rs3752089 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocates to the cytoplasm following interaction with MAPKAPK5. {ECO:0000250}. |
| Mouse PG classification | NA |
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