Gene Information

Gene Information
Gene Name	EGFR
Organism	Homo sapiens (Human)
Gene Length	1210
Protein Names	Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Target Name	epidermal growth factor receptor variant iii
Target Type	Clinical trial target
Gene Age	886 ( ENSG00000146648 )
Evolutionary Stage	Opisthokonta
AlphaFoldDB	P00533
Gene Card	EGFR
Uniprot ID	P00533
Pfam	PF00757; PF14843; PF07714; PF01030
In ASD	yes
Allosteric Prediction	yes (1.785720973)
Ortholog in Animals	Alpaca_ EGFR ( ortholog_one2one ) Dog_ EGFR ( ortholog_one2one ) GuineaPig_ EGFR ( ortholog_one2one ) Macaque_ EGFR ( ortholog_one2one ) Mouse_ Egfr ( ortholog_one2one ) Pig_ EGFR ( ortholog_one2one ) Rat_ Egfr ( ortholog_one2one ) Rabbit_ EGFR ( ortholog_one2one )
Ohnologs	ERBB3, ERBB2, ERBB4
Paralogs	EPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1, MET
Tissue	NA
Tissue Specificity	Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers. {ECO:0000269\|PubMed:17671655}.
Pharmacological Animal Models	NULL(Chimpanzee);NULL(Mouse);0.068995(Rat);0.051451(Rabbit)
Gene Ontology (biological process)
Gene Ontology (cellular component)
Gene Ontology (molecular function)
PDB	1IVO (X-ray 3.30A ) 1M14 (X-ray 2.60A ) 1M17 (X-ray 2.60A ) 1MOX (X-ray 2.50A ) 1NQL (X-ray 2.80A ) 1XKK (X-ray 2.40A ) 1YY9 (X-ray 2.60A ) 1Z9I (NMR - ) 2EB2 (X-ray 2.50A ) 2EB3 (X-ray 2.84A ) 2GS2 (X-ray 2.80A ) 2GS6 (X-ray 2.60A ) 2GS7 (X-ray 2.60A ) 2ITN (X-ray 2.47A ) 2ITO (X-ray 3.25A ) 2ITP (X-ray 2.74A ) 2ITQ (X-ray 2.68A ) 2ITT (X-ray 2.73A ) 2ITU (X-ray 2.80A ) 2ITV (X-ray 2.47A ) 2ITW (X-ray 2.88A ) 2ITX (X-ray 2.98A ) 2ITY (X-ray 3.42A ) 2ITZ (X-ray 2.72A ) 2J5E (X-ray 3.10A ) 2J5F (X-ray 3.00A ) 2J6M (X-ray 3.10A ) 2JIT (X-ray 3.10A ) 2JIU (X-ray 3.05A ) 2JIV (X-ray 3.50A ) 2KS1 (NMR - ) 2M0B (NMR - ) 2M20 (NMR - ) 2N5S (NMR - ) 2RF9 (X-ray 3.50A ) 2RFD (X-ray 3.60A ) 2RFE (X-ray 2.90A ) 2RGP (X-ray 2.00A ) 3B2U (X-ray 2.58A ) 3B2V (X-ray 3.30A ) 3BEL (X-ray 2.30A ) 3BUO (X-ray 2.60A ) 3C09 (X-ray 3.20A ) 3G5V (X-ray 2.00A ) 3G5Y (X-ray 1.59A ) 3GOP (X-ray 2.80A ) 3GT8 (X-ray 2.96A ) 3IKA (X-ray 2.90A ) 3LZB (X-ray 2.70A ) 3NJP (X-ray 3.30A ) 3OB2 (X-ray 2.10A ) 3OP0 (X-ray 2.52A ) 3P0Y (X-ray 1.80A ) 3PFV (X-ray 2.27A ) 3POZ (X-ray 1.50A ) 3QWQ (X-ray 2.75A ) 3UG1 (X-ray 2.75A ) 3UG2 (X-ray 2.50A ) 3VJN (X-ray 2.34A ) 3VJO (X-ray 2.64A ) 3VRP (X-ray 1.52A ) 3VRR (X-ray 2.00A ) 3W2O (X-ray 2.35A ) 3W2P (X-ray 2.05A ) 3W2Q (X-ray 2.20A ) 3W2R (X-ray 2.05A ) 3W2S (X-ray 1.90A ) 3W32 (X-ray 1.80A ) 3W33 (X-ray 1.70A ) 4G5J (X-ray 2.80A ) 4G5P (X-ray 3.17A ) 4HJO (X-ray 2.75A ) 4I1Z (X-ray 3.00A ) 4I20 (X-ray 3.34A ) 4I21 (X-ray 3.37A ) 4I22 (X-ray 1.71A ) 4I23 (X-ray 2.80A ) 4I24 (X-ray 1.80A ) 4JQ7 (X-ray 2.73A ) 4JQ8 (X-ray 2.83A ) 4JR3 (X-ray 2.70A ) 4JRV (X-ray 2.80A ) 4KRL (X-ray 2.85A ) 4KRM (X-ray 2.66A ) 4KRO (X-ray 3.05A ) 4KRP (X-ray 2.82A ) 4LI5 (X-ray 2.64A ) 4LL0 (X-ray 4.00A ) 4LQM (X-ray 2.50A ) 4LRM (X-ray 3.53A ) 4R3P (X-ray 2.90A ) 4R3R (X-ray 3.25A ) 4R5S (X-ray 3.00A ) 4RIW (X-ray 3.10A ) 4RIX (X-ray 3.10A ) 4RIY (X-ray 2.98A ) 4RJ4 (X-ray 2.78A ) 4RJ5 (X-ray 3.10A ) 4RJ6 (X-ray 2.70A ) 4RJ7 (X-ray 2.55A ) 4RJ8 (X-ray 2.50A ) 4TKS (X-ray 3.20A ) 4UIP (X-ray 2.95A ) 4UV7 (X-ray 2.10A ) 4WD5 (X-ray 3.30A ) 4WKQ (X-ray 1.85A ) 4WRG (X-ray 1.90A ) 4ZAU (X-ray 2.80A ) 4ZJV (X-ray 2.70A ) 4ZSE (X-ray 1.97A ) 5C8K (X-ray 3.00A ) 5C8M (X-ray 2.90A ) 5C8N (X-ray 2.40A ) 5CAL (X-ray 2.70A ) 5CAN (X-ray 2.80A ) 5CAO (X-ray 2.60A ) 5CAP (X-ray 2.40A ) 5CAQ (X-ray 2.50A ) 5CAS (X-ray 2.10A ) 5CAU (X-ray 2.25A ) 5CAV (X-ray 2.73A ) 5CNN (X-ray 1.90A ) 5CNO (X-ray 1.55A ) 5CZH (X-ray 2.80A ) 5CZI (X-ray 2.60A ) 5D41 (X-ray 2.31A ) 5EDP (X-ray 2.90A ) 5EDQ (X-ray 2.80A ) 5EDR (X-ray 2.60A ) 5EM5 (X-ray 2.65A ) 5EM6 (X-ray 2.78A ) 5EM7 (X-ray 2.81A ) 5EM8 (X-ray 2.80A ) 5FED (X-ray 2.65A ) 5FEE (X-ray 2.70A ) 5FEQ (X-ray 3.40A ) 5GMP (X-ray 2.80A ) 5GNK (X-ray 1.80A ) 5GTY (X-ray 3.14A ) 5GTZ (X-ray 3.00A ) 5HCX (X-ray 2.60A ) 5HCY (X-ray 2.46A ) 5HCZ (X-ray 2.62A ) 5HG5 (X-ray 1.52A ) 5HG7 (X-ray 1.85A ) 5HG8 (X-ray 1.42A ) 5HG9 (X-ray 2.15A ) 5HIB (X-ray 2.85A ) 5HIC (X-ray 2.60A ) 5J9Y (X-ray 2.80A ) 5J9Z (X-ray 2.50A ) 5JEB (X-ray 3.30A ) 5LV6 (NMR - ) 5SX4 (X-ray 2.80A ) 5SX5 (X-ray 2.50A ) 5U8L (X-ray 1.60A ) 5UG8 (X-ray 1.46A ) 5UG9 (X-ray 1.33A ) 5UGA (X-ray 1.82A ) 5UGB (X-ray 2.53A ) 5UGC (X-ray 1.58A ) 5UWD (X-ray 3.06A ) 5WB7 (X-ray 2.94A ) 5WB8 (X-ray 3.00A ) 5X26 (X-ray 2.95A ) 5X27 (X-ray 2.95A ) 5X28 (X-ray 2.95A ) 5X2A (X-ray 1.85A ) 5X2C (X-ray 2.05A ) 5X2F (X-ray 2.20A ) 5X2K (X-ray 3.20A ) 5XDK (X-ray 2.35A ) 5XDL (X-ray 2.70A ) 5XGM (X-ray 2.95A ) 5XGN (X-ray 3.00A ) 5XWD (X-ray 2.89A ) 5Y25 (X-ray 3.10A ) 5Y9T (X-ray 3.25A ) 5YU9 (X-ray 1.95A ) 5ZTO (X-ray 2.65A ) 5ZWJ (X-ray 2.90A ) 6ARU (X-ray 3.20A ) 6B3S (X-ray 2.80A ) 6D8E (X-ray 2.54A ) 6DUK (X-ray 2.20A ) 6JRJ (X-ray 2.94A ) 6JRK (X-ray 2.80A ) 6JRX (X-ray 2.20A ) 6JWL (X-ray 2.55A ) 6JX0 (X-ray 2.53A ) 6JX4 (X-ray 2.53A ) 6JXT (X-ray 2.31A ) 6JZ0 (X-ray 2.86A ) 6LUB (X-ray 2.31A ) 6LUD (X-ray 2.05A ) 6P1D (X-ray 2.40A ) 6P1L (X-ray 2.80A ) 6P8Q (X-ray 1.90A ) 6S89 (X-ray 2.70A ) 6S8A (X-ray 2.60A ) 6S9B (X-ray 3.25A ) 6S9C (X-ray 2.73A ) 6S9D (X-ray 2.67A ) 6TFU (X-ray 2.00A ) 6TFV (X-ray 1.50A ) 6TFW (X-ray 2.00A ) 6TFY (X-ray 1.70A ) 6TFZ (X-ray 1.80A ) 6TG0 (X-ray 1.50A ) 6TG1 (X-ray 1.60A ) 6V5N (X-ray 2.40A ) 6V5P (X-ray 2.30A ) 6V66 (X-ray 1.79A ) 6V6K (X-ray 2.20A ) 6V6O (X-ray 2.10A ) 6VH4 (X-ray 2.80A ) 6VHN (X-ray 2.40A ) 6VHP (X-ray 3.60A ) 6WA2 (X-ray 2.40A ) 6WAK (X-ray 2.40A ) 6WXN (X-ray 1.76A ) 6XL4 (X-ray 2.06A ) 6Z4B (X-ray 2.50A ) 6Z4D (X-ray 2.00A ) 7A2A (X-ray 1.90A ) 7A6I (X-ray 2.40A ) 7A6J (X-ray 2.00A ) 7A6K (X-ray 2.00A ) 7AEI (X-ray 2.65A ) 7AEM (X-ray 2.65A ) 7B85 (X-ray 2.50A ) 7ER2 (X-ray 2.66A ) 7JXI (X-ray 3.00A ) 7JXK (X-ray 3.10A ) 7JXL (X-ray 2.40A ) 7JXM (X-ray 2.19A ) 7JXP (X-ray 2.16A ) 7JXQ (X-ray 1.83A ) 7JXW (X-ray 2.50A ) 7K1H (X-ray 2.60A ) 7K1I (X-ray 3.20A ) 7KXZ (X-ray 2.40A ) 7KY0 (X-ray 3.10A ) 7LEN (X-ray 2.90A ) 7LFR (X-ray 3.20A ) 7LFS (X-ray 3.50A ) 7LG8 (X-ray 2.93A ) 7LGS (X-ray 3.10A ) 7LTX (X-ray 2.30A ) 7OM4 (X-ray 6.05A ) 7OXB (X-ray 2.56A ) 7SYD (EM 3.10A ) 7SYE (EM 3.30A ) 7SZ0 (EM 3.30A ) 7SZ1 (EM 3.40A ) 7SZ5 (EM 3.60A ) 7SZ7 (EM 3.40A ) 7TVD (X-ray 2.96A ) 7VRA (X-ray 2.41A ) 7VRE (X-ray 2.51A ) 8D73 (X-ray 2.17A ) 8D76 (X-ray 2.40A )
DBSNP	rs17289589 rs17336639 rs606231253 rs2227983 rs17337079 rs397517085 rs397517085 rs727504256 rs121913428 rs28929495 rs121913428 rs28929495 rs1051753269 rs121913420 rs121913465 rs147149347 rs121434569 rs397517126 rs397517127 rs397517128 rs864621996 rs121913443 rs121434568 rs121913444 rs17337451 rs17290699 rs34352568 rs35918369
Subcellular location [CC]	Cell membrane {ECO:0000269\|PubMed:17182860, ECO:0000269\|PubMed:20462955, ECO:0000269\|PubMed:23589287, ECO:0000269\|PubMed:27153536, ECO:0000269\|PubMed:2790960}; Single-pass type I membrane protein {ECO:0000269\|PubMed:27153536}. Endoplasmic reticulum membrane {ECO:0000269\|PubMed:27153536}; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Endosome {ECO:0000269\|PubMed:17182860, ECO:0000269\|PubMed:27153536}. Endosome membrane. Nucleus {ECO:0000269\|PubMed:17115032, ECO:0000269\|PubMed:17909029, ECO:0000269\|PubMed:20551055, ECO:0000269\|PubMed:20674546}. Note=In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:20674546, PubMed:17909029). Endocytosed upon activation by ligand (PubMed:2790960, PubMed:17182860, PubMed:27153536, PubMed:17909029). Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055). {ECO:0000269\|PubMed:17182860, ECO:0000269\|PubMed:17909029, ECO:0000269\|PubMed:20674546, ECO:0000269\|PubMed:27153536, ECO:0000269\|PubMed:2790960}.; [Isoform 2]: Secreted.
Mouse PG classification	NA
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