| Gene Information | |
|---|---|
| Gene Name | EGF |
| Organism | Homo sapiens (Human) |
| Gene Length | 1207 |
| Protein Names | Pro-epidermal growth factor (EGF) [Cleaved into: Epidermal growth factor (Urogastrone)] |
| Target Name | epidermal growth factor |
| Target Type | Successful target |
| Gene Age | 987 ( ENSG00000138798 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P01133 |
| Gene Card | EGF |
| Uniprot ID | P01133 |
| Pfam | PF00008; PF07645; PF00058 |
| In ASD | no |
| Allosteric Prediction | yes (1.602951355) |
| Ortholog in Animals | Alpaca_ EGF ( ortholog_one2one ) Dog_ EGF ( ortholog_one2one ) GuineaPig_ EGF ( ortholog_one2one ) Macaque_ EGF ( ortholog_one2one ) Mouse_ Egf ( ortholog_one2one ) Pig_ EGF ( ortholog_one2one ) Rat_ Egf ( ortholog_one2one ) Rabbit_ EGF ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LDLR, LRP12, LRP2, LRP1, VLDLR, LRP4, LRP5, LRP1B, NID2, LRP6, LRP3, LRP8, LRP10, NID1 |
| Tissue | kidney, pancreas |
| Tissue Specificity | Expressed in kidney, salivary gland, cerebrum and prostate. {ECO:0000269|PubMed:17671655}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.025(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 1IVO (X-ray 3.30A ) 1JL9 (X-ray 3.00A ) 1NQL (X-ray 2.80A ) 1P9J (NMR - ) 2KV4 (NMR - ) 3NJP (X-ray 3.30A ) 7OM4 (X-ray 6.05A ) 7SYD (EM 3.10A ) 7SYE (EM 3.30A ) 7SZ0 (EM 3.30A ) 7SZ1 (EM 3.40A ) |
| DBSNP | rs11568849 rs9991664 rs11568911 rs35191533 rs11568943 rs11568992 rs2237051 rs6413481 rs11569017 rs11569046 rs4698803 rs11569086 rs11569098 rs121434567 rs11569111 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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