Gene Information
Gene NameEFNA4
OrganismHomo sapiens (Human)
Gene Length201
Protein NamesEphrin-A4 (EPH-related receptor tyrosine kinase ligand 4) (LERK-4)
Target NameNA
Target TypeNA
Gene Age332 ( ENSG00000243364 )
Evolutionary StageEumetazoa
AlphaFoldDBP52798
Gene CardEFNA4
Uniprot IDP52798
PfamPF00812
In ASDno
Allosteric Predictionno (-0.772900356)
Ortholog in AnimalsAlpaca_ EFNA4 ( ortholog_one2one )
Dog_ EFNA4 ( ortholog_one2one )
GuineaPig_ EFNA4 ( ortholog_one2one )
Mouse_ Efna4 ( ortholog_one2one )
Pig_ EFNA4 ( ortholog_one2one )
Rat_ Efna4 ( ortholog_one2one )
Rabbit_ EFNA4 ( ortholog_one2one )
OhnologsNA
ParalogsEFNB2, EFNA2, EFNB3, EFNB1, EFNA1, EFNA3, EFNA5
TissueNA
Tissue SpecificityExpressed in the adult spleen, lymph node, prostate, ovary, small intestine, and colon, and in fetal heart, lung, liver and kidney. Also detected in hematopoietic cell lines.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP NA 
Subcellular location [CC][Isoform 1]: Cell membrane;
Lipid-anchor, GPI-anchor.;
[Isoform 2]: Secreted {ECO:0000305}.
Mouse PG classificationNA
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