| Gene Information | |
|---|---|
| Gene Name | EFL3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 346 |
| Protein Names | Ephrin-B1 (EFL-3) (ELK ligand) (ELK-L) (EPH-related receptor tyrosine kinase ligand 2) (LERK-2) [Cleaved into: Ephrin-B1 C-terminal fragment (Ephrin-B1 CTF); Ephrin-B1 intracellular domain (Ephrin-B1 ICD)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P98172 |
| Gene Card | EFNB1 |
| Uniprot ID | P98172 |
| Pfam | PF00812 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed (PubMed:8070404, PubMed:7973638). Detected in both neuronal and non-neuronal tissues (PubMed:8070404, PubMed:7973638). Seems to have particularly strong expression in retina, sciatic nerve, heart and spinal cord (PubMed:7973638). {ECO:0000269|PubMed:7973638, ECO:0000269|PubMed:8070404}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6THG (X-ray 4.07A ) |
| DBSNP | rs104894801 rs104894796 rs2080471329 rs28936069 rs28936070 rs146636295 rs28935170 rs28936071 rs7889678 rs16989105 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10197531, ECO:0000269|PubMed:7973638}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:10197531}. Note=May recruit GRIP1 and GRIP2 to membrane raft domains. {ECO:0000269|PubMed:10197531}.; [Ephrin-B1 C-terminal fragment]: Cell membrane {ECO:0000269|PubMed:16930449}; Single-pass type I membrane protein {ECO:0000305}.; [Ephrin-B1 intracellular domain]: Nucleus {ECO:0000269|PubMed:16930449}. Note=Colocalizes with ZHX2 in the nucleus. {ECO:0000250|UniProtKB:P52795}. |
| Mouse PG classification | NA |
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