| Gene Information | |
|---|---|
| Gene Name | TM4SF20 |
| Organism | Homo sapiens (Human) |
| Gene Length | 229 |
| Protein Names | Transmembrane 4 L6 family member 20 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000168955 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q53R12 |
| Gene Card | TM4SF20 |
| Uniprot ID | Q53R12 |
| Pfam | PF05805 |
| In ASD | no |
| Allosteric Prediction | no (-1.590055248) |
| Ortholog in Animals | Alpaca_ TM4SF20 ( ortholog_one2one ) Dog_ TM4SF20 ( ortholog_one2one ) GuineaPig_ TM4SF20 ( ortholog_one2one ) Macaque_ TM4SF20 ( ortholog_one2one ) Mouse_ Tm4sf20 ( ortholog_one2one ) Pig_ TM4SF20 ( ortholog_one2one ) Rat_ Tm4sf20 ( ortholog_one2one ) Rabbit_ TM4SF20 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TM4SF19, TM4SF4, TM4SF18, TM4SF1, TM4SF5 |
| Tissue | duodenum, small.intestine, small.intestine.Peyers.patch |
| Tissue Specificity | Expressed in the brain, with high levels in the parietal lobe, hippocampus, pons, white matter and cerebellum. {ECO:0000269|PubMed:23810381}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs7574414 |
| Subcellular location [CC] | Membrane {ECO:0000269|PubMed:23810381}; Multi-pass membrane protein {ECO:0000269|PubMed:23810381}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:25310401}; Multi-pass membrane protein {ECO:0000269|PubMed:25310401}. Note=Ceramide alters the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20. {ECO:0000269|PubMed:27499293}. |
| Mouse PG classification | NA |
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