| Gene Information | |
|---|---|
| Gene Name | EFCAB4B |
| Organism | Homo sapiens (Human) |
| Gene Length | 731 |
| Protein Names | EF-hand calcium-binding domain-containing protein 4B (Calcium release-activated calcium channel regulator 2A) (CRAC channel regulator 2A) (Calcium release-activated channel regulator 2A) (Ras-related protein Rab-46) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9BSW2 |
| Gene Card | CRACR2A |
| Uniprot ID | Q9BSW2 |
| Pfam | PF13499; PF00071 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | [Isoform 1]: Expressed in the Jurkat T-cell line. {ECO:0000269|PubMed:27016526}.; [Isoform 2]: Expressed in endothelial cells (PubMed:25475730). Expressed in Weibel-Palade bodies (which are P-selectin/SELP negative) in endothelial cells (PubMed:31092558). Expressed in the Jurkat T-cell line (PubMed:30814157, PubMed:27016526). {ECO:0000269|PubMed:25475730, ECO:0000269|PubMed:27016526, ECO:0000269|PubMed:30814157, ECO:0000269|PubMed:31092558}. |
| Pharmacological Animal Models | 0.031082(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6PSD (X-ray 2.66A ) |
| DBSNP | rs9788233 rs17836273 rs242017 rs34088152 rs242018 rs36030417 |
| Subcellular location [CC] | [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:20418871}.; [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:30814157, ECO:0000269|PubMed:31092558}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:30814157, ECO:0000269|PubMed:31092558}. Cell membrane {ECO:0000269|PubMed:30814157}. Golgi apparatus membrane {ECO:0000269|PubMed:27016526}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:27016526}. Vesicle {ECO:0000269|PubMed:27016526}. Note=T-cell activation-induced elevation of intracellular of Ca(2+) stimulates its transport toward the microtubule organizing center (MTOC) (PubMed:30814157). Histamine stimulation induces a trafficking to the MTOC in a GTP-binding-dependent but Ca(2+)-binding-independent manner (PubMed:31092558). Localizes to Golgi membrane in resting T-cells and upon its interaction with VAV1, is translocated from the Golgi membrane to the immunological synapse via subsynaptic vesicles (PubMed:27016526). Its localization in the Golgi membrane requires isoprenylation and GTP-binding (PubMed:27016526). {ECO:0000269|PubMed:27016526, ECO:0000269|PubMed:30814157, ECO:0000269|PubMed:31092558}. |
| Mouse PG classification | NA |
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