| Gene Information | |
|---|---|
| Gene Name | EEF2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 858 |
| Protein Names | Elongation factor 2 (EF-2) |
| Target Name | elongation factor 2 |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000167658 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P13639 |
| Gene Card | EEF2 |
| Uniprot ID | P13639 |
| Pfam | PF00679; PF14492; PF03764; PF00009; PF03144 |
| In ASD | no |
| Allosteric Prediction | yes (1.404741427) |
| Ortholog in Animals | Alpaca_ EEF2 ( ortholog_one2one ) Dog_ EEF2 ( ortholog_one2one ) GuineaPig_ EEF2 ( ortholog_one2one ) Macaque_ EEF2 ( ortholog_one2one ) Mouse_ Eef2 ( ortholog_one2one ) Pig_ EEF2 ( ortholog_one2one ) Rat_ Eef2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | EFTUD2, EIF2S3, EIF2S3B, GTPBP1, GUF1, EIF5B, MTIF2, EFL1, GSPT2, EEFSEC, EEF1A1, EEF1A2, HBS1L, GTPBP2, GFM2, GFM1, GSPT1, TUFM |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4V6X (EM 5.00A ) 6D9J (EM 3.20A ) 6Z6M (EM 3.10A ) 6Z6N (EM 2.90A ) |
| DBSNP | rs587777052 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:25064856}. Nucleus {ECO:0000269|PubMed:24648518}. Note=Phosphorylation by CSK promotes cleavage and SUMOylation-dependent nuclear translocation of the C-terminal cleavage product. {ECO:0000269|PubMed:24648518}. |
| Mouse PG classification | LPG |
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